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CASE REPORT article

Front. Oncol.
Sec. Genitourinary Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1508600

Case Report: Clinical and Molecular Features of Renal Gastrointestinal Tumor

Provisionally accepted
Simran Makker Simran Makker 1Rayan Rammal Rayan Rammal 2Ping Gu Ping Gu 3Guido Dalbagni Guido Dalbagni 4Hikmat Al-Ahmadie Hikmat Al-Ahmadie 2Narasimhan P Agaram Narasimhan P Agaram 2Gopa Iyer Gopa Iyer 3Ritesh Kotecha Ritesh Kotecha 3*
  • 1 Laurel Springs School, Ojai, California, United States
  • 2 Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, United States
  • 3 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States
  • 4 Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, United States

The final, formatted version of the article will be published soon.

    While gastrointestinal stromal tumors (GISTs) often arise within the GI tract, it is well known that GISTs may also rarely emanate outside of the digestive system. Prior case reports have documented various primary sites in non-GI organs (extra-intestinal GIST, or EGIST), yet only one report has described a localized GIST of renal origin. Here, we describe a patient who presented with bilateral renal masses who was found to have a large unresectable renal GIST tumor treated with imatinib. We discuss treatment experience and response with systemic therapy and describe molecular data to contextualize this ultra-rare presentation within the landscape of EGIST tumors.

    Keywords: Gastrointestinal Stromal Tumor, GIST, renal mass, Imatinib, KIT

    Received: 09 Oct 2024; Accepted: 17 Jan 2025.

    Copyright: © 2025 Makker, Rammal, Gu, Dalbagni, Al-Ahmadie, Agaram, Iyer and Kotecha. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ritesh Kotecha, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, New York, United States

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