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SYSTEMATIC REVIEW article

Front. Oncol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1508173

Bibliometric analysis: A study of the microenvironment in cervical cancer (2000-2024)

Provisionally accepted
Yuntao Zhang Yuntao Zhang 1,2Yanni Wei Yanni Wei 3Chenchen Liu Chenchen Liu 4Maiqing Yang Maiqing Yang 4*
  • 1 changyi people's hospital, changyi, China
  • 2 changyi people', changyi, China
  • 3 Weifang Nursing Vocational College, Weifang, Shandong Province, China
  • 4 Weifang People's Hospital, Weifang, Shandong Province, China

The final, formatted version of the article will be published soon.

    Objective: The incidence of cervical cancer has increased in recent years. The tumor microenvironment (TME) is the local biological environment involved in tumor occurrence and development. This study aimed to conduct a comprehensive analysis of the global research on the TME in cervical cancer (CC), providing a knowledge framework in this field from a holistic and systematic perspective based on a bibliometric analysis. Methods: Studies focusing on the TME in cervical cancer were searched using the Web of Science Core Collection database. The annual output, cooperation, hotspots, research status, and development trends in this field were analyzed using bibliometric softwares (VOSviewer and CiteSpace). Results: A total of 1,057 articles published between 2000 and 2024 were selected. The number of publications and citations has recently increased. Cooperation network analysis indicated that China holds the foremost position in research on the TME in cervical cancer with the highest volume of publications, thus exerting the greatest influence. Fudan University had the highest output. Frontiers in Oncology showed the highest degree of productivity in this field. Rofstad, Einar K. made the most article contributions and was the most co-cited author. Four clusters were obtained after a cluster analysis of the keywords: TME, cervical cancer, immunotherapy, and prognosis. Immunotherapy, human papillomavirus, and biomarkers were relatively recent keywords that attracted increasing attention from researchers. Discussion: This bibliometric analysis provides a data-based and objective introduction to the TME of cervical cancer, and offers readers a valuable reference for future research. Conclusions: Comprehensive research in this field was mainly distributed in the TME of cervical cancer through the analysis of keywords and documents. Sufficient evidence supports mechanism research and application exploration. Further research should explore new topics related to the TME of cervical cancer.

    Keywords: cc, cervial cancer cervical cancer, Tumor Microenvironment, bibliometric analysis, VOSviewer, Citespace

    Received: 08 Oct 2024; Accepted: 06 Feb 2025.

    Copyright: © 2025 Zhang, Wei, Liu and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Maiqing Yang, Weifang People's Hospital, Weifang, 261000, Shandong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.