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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1506521
This article is part of the Research Topic Exploring HPV's Role in Genitourinary Cancers Beyond Cervical Cancer View all 4 articles

Investigating the Impact of Persistent HPV Infection on Recurrence of Lesions Post-Surgery for Early-Stage Cervical Cancer and Related Influencing Factors

Provisionally accepted
Jing Na Jing Na Ya Li Ya Li Qiao Lu Qiao Lu Yang Wang Yang Wang Han Shichao Han Shichao *Jun Wang Jun Wang *
  • Department of Obstetrics and Gynecology, Second Affiliated Hospital of Dalian Medical University, Dalian, China

The final, formatted version of the article will be published soon.

    Objective：To explore the influencing factors of recurrence after surgical treatment for early-stage cervical cancer (stages IA1-IIA1) and to investigate the relationship between human papillomavirus (HPV) infection and postoperative recurrence of lesions.： A retrospective analysis was conducted on the clinical data of 242 patients who underwent surgical treatment for early-stage cervical cancer (FIGO stages IA1-IIA1) at the Second Affiliated Hospital of Dalian Medical University between 2015 and 2022. Cox regression analysis was employed to evaluate the relationship between persistent postoperative HPV infection and lesion vaginal local recurrence while identifying the associated risk factors for persistent HPV infection following surgery.Results：Within 12 months postoperatively, the HPV clearance rate was 88.11%. HPV infection persisted beyond 12 months in 19 patients (7.9%), with 3 cases demonstrating the same HPV genotypes (types 52, 58) as those identified preoperatively. Multivariate analysis identified persistent postoperative HPV infection (odds ratio [OR] 1.72, 95% confidence interval [CI] -1.14 to 5, p=0.001*) as an independent risk factor for recurrence. Additionally, smoking (OR 7.49, 95% CI 1.19 to 47.13, p=0.032), abnormal vaginal microbiota (OR 0.663, 95% CI 0.403 to 1.088, p=0.001*), and the type of surgical procedure (OR 0.32, 95% CI 0.11 to 0.91, p=0.033) were significantly associated with a higher rate of persistent HPV infection.Conclusion：Persistent HPV infection after surgery is an independent risk factor for postoperative recurrence in early-stage cervical cancer. Surgical approach, abnormal vaginal microbiota, and smoking are associated factors for persistent HPV infection after surgery.

    Keywords: ：HPV infections, Cervical carcinoma, Hysterectomy, Recurrence, HPV - human papillomavirus

    Received: 07 Oct 2024; Accepted: 16 Jan 2025.

    Copyright: © 2025 Na, Li, Lu, Wang, Shichao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Han Shichao, Department of Obstetrics and Gynecology, Second Affiliated Hospital of Dalian Medical University, Dalian, China
    Jun Wang, Department of Obstetrics and Gynecology, Second Affiliated Hospital of Dalian Medical University, Dalian, China

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