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CASE REPORT article

Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1505504

Uterine Carcinosarcoma with Heterologous Osseous Elements: A Case Report of an Extremely Rare Clinical Occurrence with Literature Review

Provisionally accepted
Hiba AlDallal Hiba AlDallal 1Taylor H Jacobs Taylor H Jacobs 2Cody Bergman Cody Bergman 1*Siddharth Narayanan Siddharth Narayanan 2Arshi Kaur Arshi Kaur 1*Samer Z Al-Quran Samer Z Al-Quran 1*Harpreet Kaur Chopra Harpreet Kaur Chopra 1*
  • 1 University of Louisville, Louisville, Colorado, United States
  • 2 Nationwide Children's Hospital, Columbus, United States

The final, formatted version of the article will be published soon.

    Carcinosarcoma is a rare and aggressive malignant neoplasm that predominantly affects elderly postmenopausal women and can involve various gynecologic organs. It is characterized by the presence of both malignant epithelial and sarcomatous components. While most uterine carcinosarcomas (UCS) are homologous (sarcomatous component consisting of elements native to the uterus), heterologous components are less common and may vary in composition. Rare heterologous elements can include lipomatous (liposarcoma) or osseous elements (osteosarcoma). We present an unusual case of a 31-year-old female with UCS exhibiting osseous heterologous elements. The patient underwent successful surgical resection and remains in remission during follow-up. This case is notable for its rarity, as highlighted by the uncommon age of the patient and the presence of rare heterologous elements in the UCS. Furthermore, it provides new insights into the diverse presentations of UCS and underscores the importance of comprehensive evaluation in understanding its clinical manifestations.

    Keywords: Uterus, tumor, Carcinosarcoma, Osteosarcoma, Cancer, malignant

    Received: 03 Oct 2024; Accepted: 24 Jan 2025.

    Copyright: © 2025 AlDallal, Jacobs, Bergman, Narayanan, Kaur, Al-Quran and Chopra. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Cody Bergman, University of Louisville, Louisville, 40292, Colorado, United States
    Arshi Kaur, University of Louisville, Louisville, 40292, Colorado, United States
    Samer Z Al-Quran, University of Louisville, Louisville, 40292, Colorado, United States
    Harpreet Kaur Chopra, University of Louisville, Louisville, 40292, Colorado, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.