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CASE REPORT article
Front. Oncol.
Sec. Surgical Oncology
Volume 15 - 2025 |
doi: 10.3389/fonc.2025.1504366
Article type: Case report. Title：BRCA1 and BRCA2 loss in a Young Man with Primary Cutaneous Extraskeletal Osteosarcoma
Provisionally accepted- 1 Guangdong Medical University, Zhanjiang, China
- 2 People's Hospital of Yangjiang, Yangjiang, Guangdong Province, China
A 28-year-old man was hospitalized for a skin mass on the left shoulder. The histological examination showed a large number of tumor giant cells and fibroblasts, and nuclear division was easy to see . Immunohistochemistry showed positive for CK, EMA, S100, CD34, CK7, Bcl-2, ACTin, and NSE, and nagetive for Vim, SATB2, CD99, SMA(focal), and Ki67 was about 40%. Shoulder joint CT and PET-CT showed that no metastasis presented. Germline testing showed decreased copy number of BRCA1 and BRCA2 . The diagnosis was cutaneous extraskeletal osteosarcomas of the left shoulder. The patient underwent an enlarged resection, followed by local radiotherapy four cycles. No recurrence or metastasis occurred on a 1-year of follow-up.
Keywords: Osteosarcoma, Primary cutaneous extraskeletal osteosarcoma, Soft tissue tumor, BRCA1, BRCA2
Received: 30 Sep 2024; Accepted: 03 Feb 2025.
Copyright: © 2025 Luo, Hou, Huang, Lai, Jiang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wei-Liang Wang, People's Hospital of Yangjiang, Yangjiang, 529500, Guangdong Province, China
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