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REVIEW article
Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1502673
Research progress of ferroptosis pathway and its related molecular ubiquitination modification in liver cancer
Provisionally accepted
Silin Yao 1
Yi Quan 2*- 1 First Clinical Medical College, Guangdong Medical University, Zhanjiang, China
- 2 The First People’s Hospital of Zhaoqing,Guangdong Medical University, Zhaoqing, Guangdong, China., Zhaoqing, Guangdong,, China
As a new type of programmed cell death, ferroptosis is characterized by iron metabolism disorder and reactive oxygen species (ROS) accumulation, and is involved in regulating the occurrence and development of cancer cells. Especially in the field of liver cancer treatment, ferroptosis shows great potential because it can induce tumor cell death. Ubiquitination is a process of protein posttranslational modification, which can affect the stability of proteins and regulate the progress of ferroptosis. This article reviews the research progress of ubiquitination modification of molecules related to ferroptosis pathway in the regulation of liver cancer, providing a new strategy for the treatment of liver cancer.
Keywords: liver cancer, Ubiquitin, ferroptosis, Lipid Peroxidation, targeted therapy
Received: 27 Sep 2024; Accepted: 06 Mar 2025.
Copyright: © 2025 Yao and Quan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yi Quan, The First People’s Hospital of Zhaoqing,Guangdong Medical University, Zhaoqing, Guangdong, China., Zhaoqing, Guangdong,, China
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