Skip to main content

CASE REPORT article

Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1502574

Intravascular large B-cell lymphoma of the central nervous system with renal involvement : a case report and literature review

Provisionally accepted
Jun Li Jun Li 1,2*Zhaojiao Li Zhaojiao Li 1,2Yifeng Shi Yifeng Shi 3Jiajie Chen Jiajie Chen 1Heng Zhao Heng Zhao 3Xueye Mao Xueye Mao 1Shan Li Shan Li 1Huiying Wang Huiying Wang 1,2Qiang Meng Qiang Meng 1*Lingchun Liu Lingchun Liu 1*
  • 1 Department of Neurology, The First People’s Hospital of Yunnan Province, Kunming, China
  • 2 School of Medicine, Kunming University of Science and Technology, Kunming, Yunnan Province, China
  • 3 Department of Neurosurgery, The First People’s Hospital of Yunnan Province, Kunming, Yunnan Province, China

The final, formatted version of the article will be published soon.

    Intravascular large B-cell lymphoma (IVLBCL) is a highly aggressive type of non-Hodgkin's lymphoma. The clinical manifestations and imaging of this disease are nonspecific, making diagnosis challenging. We report a case of a patient with recurrent stroke-like symptoms, primarily characterized by hemiplegia, vertigo, ataxia, and proteinuria. Brain MRI revealed multiple cerebral infarctions, microbleeds, and meningeal enhancement. Ultimately, the patient was diagnosed with IVLBCL through a brain tissue biopsy, and involvement of the kidneys was suspected.We suggest considering IVLBCL in patients who present with recurrent stroke-like symptoms, fluctuating neurological deficits, the aforementioned MRI findings, and involvement of other organs. Additionally, central nervous system vasculitis（CNSV） may represent a transitional manifestation of the disease. Pathological biopsy is the gold standard for diagnosis. We hope that through this case, doctors can gain a deeper understanding of IVLBCL, enabling early diagnosis and timely treatment to improve prognosis.

    Keywords: Intravascular large B-cell lymphoma1, central nervous system vasculitis2, MRI imaging features3, pathology biopsy 4, differential diagnosis5

    Received: 30 Sep 2024; Accepted: 13 Jan 2025.

    Copyright: © 2025 Li, Li, Shi, Chen, Zhao, Mao, Li, Wang, Meng and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jun Li, Department of Neurology, The First People’s Hospital of Yunnan Province, Kunming, China
    Qiang Meng, Department of Neurology, The First People’s Hospital of Yunnan Province, Kunming, China
    Lingchun Liu, Department of Neurology, The First People’s Hospital of Yunnan Province, Kunming, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.