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CASE REPORT article
Front. Oncol.
Sec. Genitourinary Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1501820
Metastatic MiT family/TFE translocation renal cell carcinoma in adults:case series reports and literature reviews
Provisionally accepted- Bethune First Hospital of Jilin University, Changchun, China
This article presents a case study of three patients diagnosed with MiT/TFE tRCC at our hospital.The tumors were located in the left kidney of all three patients, with two of them being under 30 years old. Within a short timeframe, two of all patients developed liver metastases. Genetic testing was conducted in one case, FISH testing in another, and all cases underwent a combination of targeted therapy and immunotherapy. By analyzing the clinical, pathological, and genomic characteristics of these patients, this article aims to enhance the understanding of MiT family translocation renal cell carcinoma, as well as improve the diagnosis, treatment, and prognosis of this rare form of renal cell carcinoma. Further evidence is provided to support these findings.
Keywords: Mit family translocation renal cell carcinoma (MiT/TFE tRCC)1, molecular characterization2, Genetic Mutation3, Biological behavior4, targeted therapy5, Clinical management6
Received: 25 Sep 2024; Accepted: 03 Mar 2025.
Copyright: © 2025 Sun, Wang, Man, Chen, Cong, Zhang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lei Yang, Bethune First Hospital of Jilin University, Changchun, China
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