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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Head and Neck Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1498609
This article is part of the Research TopicAdvancing Cancer Imaging Technologies: Bridging the Gap from Research to Clinical Practice Volume IIView all 6 articles
Clinical and Imaging Features of Primary Thyroid MALT Lymphoma
Provisionally accepted- 1Department of Nuclear Medicine, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China
- 2NHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, Mianyang, China
- 3Department of Pathology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China
- 4Department of Ultrasound, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China
- 5Department of Hematology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China
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Primary thyroid lymphoma is a rare hematologic malignancy of the thyroid gland, accounting for approximately 5% of all malignant thyroid tumors. The most common pathological type is B-cell-derived non-Hodgkin's lymphoma, mainly diffuse large B-cell lymphoma, followed by mucosa-associated lymphoid tissue lymphoma and mixed types. The clinical and radiographic characteristics of primary thyroid lymphoma are non-specific, often leading to misdiagnosis as thyroiditis and a delay in treatment. A 60-year-old woman was referred to our hospital with neck swelling that had persisted for a week. Histopathological findings of a thyroid biopsy revealed mucosa-associated lymphoid tissue lymphoma. Bone marrow examination revealed atypical lymphocytes on myelograms. [ 18 F]FDG PET/CT images showed increased [ 18 F]FDG uptake in both lobes of the thyroid gland and the cervical lymph nodes. The patient was diagnosed with stage IV primary thyroid mucosa-associated lymphoid tissue lymphoma. The patient subsequently received four cycles of R-CEOP chemotherapy and remained under follow-up. Due to the rarity of this case, we conducted a systematic literature review to better understand the disease and improve timely diagnosis and treatment.
Keywords: Primary thyroid lymphoma, Mucosa-associated lymphoid tissue lymphoma, case report, System review, literature review
Received: 21 Sep 2024; Accepted: 16 Apr 2025.
Copyright: © 2025 Xiao, Zhao, Zhou, Yan, Luo, Liu, Zhou and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dan Huang, Department of Nuclear Medicine, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China
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