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CASE REPORT article
Front. Oncol.
Sec. Breast Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1496057
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A 64-year-old woman presented with no abnormalities in the axillary lymph nodes on clinical presentation or imaging. After diagnosis of malignant adenomyoepithelioma, the patient underwent unilateral mastectomy. Six months after surgery, the patient developed ipsilateral axillary lymph node enlargement, which was confirmed by pathologic examination to be the result of metastasis of malignant adenomyoepithelioma of the breast to the axillary lymph nodes. The patient underwent axillary lymph node dissection, followed by 4 cycles of epirubicin and cyclophosphamide (AC) chemotherapy. Twelve months after the operation, the patient came to our outpatient clinic for follow-up, and the examination results showed no signs of recurrence or distant metastasis.We meticulously described the clinical symptoms, signs, as well as the imaging characteristics of both the primary lesion of malignant adenomyoepithelioma of the breast and its axillary metastasis in the patient. Through a comparison of the pathologic traits between the primary breast lesion and the axillary metastatic lymph nodes, it was discovered that there existed a certain degree of consistency in terms of microscopic pathologic features and immunohistochemical molecular expression.
Keywords: Malignant adenomyoepithelioma, Axillary lymph node metastasis, Molecular expression, case report, literature review
Received: 13 Sep 2024; Accepted: 31 Jan 2025.
Copyright: © 2025 . This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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