Skip to main content

REVIEW article

Front. Oncol.
Sec. Cancer Molecular Targets and Therapeutics
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1495617
This article is part of the Research Topic Renewed Insight into Cancer Mechanism and Therapy View all 8 articles

Ferroptosis in Thyroid Cancer: Mechanisms, Current Status, and Treatment

Provisionally accepted
Wenzhi Tian Wenzhi Tian 1,2Xi Su Xi Su 1Chenchen Hu Chenchen Hu 1Dong Chen Dong Chen 1*Peng Li Peng Li 1*
  • 1 Department of Thyroid and Breast Surgery, Shenzhen Hospital, Peking University, Shenzhen, China
  • 2 Shenzhen University Health Science Centre, Shenzhen, China

The final, formatted version of the article will be published soon.

    Thyroid cancer (TC) represents the most prevalent malignancy within the endocrine system. In recent years, there has been a marked global increase in the incidence of thyroid cancer, garnering substantial scientific interest. Comprehensive investigations into the pathogenesis of TC have identified a significant association with ferroptosis, a newly characterized form of cell death mediated by iron ions. Distinct from apoptosis, necrosis, and autophagy, ferroptosis is characterized by the accumulation of lipid peroxides and reactive oxygen species, culminating in cellular damage and death.Recent research has elucidated a connection between ferroptosis and the initiation, progression, and treatment of thyroid cancer. These findings underscore the significance of ferroptosis in thyroid cancer and offer valuable insights into the development of novel therapeutic strategies and precise predictive markers. The unique mechanisms of ferroptosis present opportunities for targeting treatment-resistant thyroid cancers. Consequently, the regulation of ferroptosis may emerge as a novel therapeutic target, potentially addressing the limitations of current treatments. Moreover, elucidating the molecular mechanisms underpinning ferroptosis in thyroid cancer may facilitate the identification of novel biomarkers for early detection and prognostication. This review endeavors to synthesize the extant knowledge regarding the role of ferroptosis in thyroid cancer, examine potential therapeutic implications, and propose future research trajectories to enhance the understanding and clinical application of ferroptosis.

    Keywords: thyroid cancer, ferroptosis, mechanisms, therapeutic targets, Reactive Oxygen Species

    Received: 12 Sep 2024; Accepted: 06 Jan 2025.

    Copyright: © 2025 Tian, Su, Hu, Chen and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Dong Chen, Department of Thyroid and Breast Surgery, Shenzhen Hospital, Peking University, Shenzhen, 518036, China
    Peng Li, Department of Thyroid and Breast Surgery, Shenzhen Hospital, Peking University, Shenzhen, 518036, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.