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CASE REPORT article

Front. Oncol.
Sec. Surgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1490271

Solitary Fibular Metastasis from Lung Adenocarcinoma with Gene Mutation: A Case Report

Provisionally accepted
AHMAD KHALEEL MOHAMMAD ALKHATATBEH AHMAD KHALEEL MOHAMMAD ALKHATATBEH 1Jie Chen Chen Jie Chen Chen 1Yinbing Lin Yinbing Lin 2Xiao Lin Lu Xiao Lin Lu 1Bin Chen Bin Chen 1Hong Jiang Chen Hong Jiang Chen 1Xiao Hui Lu Xiao Hui Lu 1Hansheng Wu Hansheng Wu 3Jun Hu Jun Hu 1*
  • 1 Department of Orthopedics Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China
  • 2 Department of Radiation Oncology, Shantou University Medical College Cancer Hospital, Shantou, China
  • 3 Department of Thoracic Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

The final, formatted version of the article will be published soon.

    Solitary fibular metastasis from lung adenocarcinoma is exceedingly rare, with only five documented cases. This report presents a 40-year-old non-smoking Asian male who initially presented with painful swelling in the right knee. Imaging revealed bony destruction of the right fibular head, and further investigations with chest CT, PET/C, pathologic biopsy and genetic testing identified a primary lung adenocarcinoma with EGFR exon 19 deletion mutation. The patient was treated with Osimertinib, resulting in significant tumor reduction. This was followed by thoracoscopic lobectomy and systematic lymph node dissection, and local radiotherapy for the fibular metastasis. The patient experienced complete pain relief and showed no recurrence or metastasis over a 26-month follow-up. This case highlights the diagnostic challenge posed by atypical presentations of metastasis and underscores the importance of comprehensive evaluation, adherence to treatment guidelines, and a multidisciplinary approach in managing oncological patients. The successful outcome in this young patient emphasizes the effectiveness of personalized treatment strategies in optimizing patient prognosis, offering valuable insights for similar clinical scenarios.

    Keywords: solitary fibular metastasis, NSCLC, Osimertinib, case report, multidisciplinary

    Received: 02 Sep 2024; Accepted: 03 Jan 2025.

    Copyright: © 2025 ALKHATATBEH, Chen, Lin, Lu, Chen, Chen, Lu, Wu and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jun Hu, Department of Orthopedics Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

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