Skip to main content

REVIEW article

Front. Oncol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1489974

Review: Performance of jujube and its extracts in cancer: therapeutic, toxicityreducing and potentiating effects

Provisionally accepted
Boyun Gou Boyun Gou 1Guoqing Chen Guoqing Chen 1Shicong Huang Shicong Huang 1Na Ning Na Ning 1Qian Gu Qian Gu 1Shuai Duan Shuai Duan 1Yuhua Du Yuhua Du 1Yi Nan Yi Nan 2*Ling Yuan Ling Yuan 1*
  • 1 School of Pharmacy, Ningxia Medical University, Yinchuan, China
  • 2 Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, Ningxia Hui Region, China

The final, formatted version of the article will be published soon.

    Cancer is one of the most serious public health challenges in the world. The number of new and fatal patients with cancer continues to increase every year, which poses a serious threat to human health. Although there are effective treatments such as radiotherapy and chemotherapy for cancers, they are often accompanied by serious side effects. With the development of the pharmaceutical industry, there is a gradual desire to develop low-toxicity and effective anticancer drugs from traditional Chinese herbs.Due to its "homology of medicine and food," jujube is one of the traditional Chinese herbs that is extensively used in China. In addition, jujube has received much attention around the world for its excellent pharmacological effects and food value. This article reviews the anticancer effects of a fruit, food, and drug, jujube, which have been shown in current studies, and analyzes its therapeutic mechanism, active ingredients, extraction and isolation methods, as well as its synergistic and attenuation performance in cancer. This will further promote the progress of natural medicine's anti-cancer effect.

    Keywords: Jujube, Homology of medicine and food, anti-cancer, Adverse Reactions, Extraction and separation, Attenuated toxicity and potentiating effects

    Received: 02 Sep 2024; Accepted: 06 Jan 2025.

    Copyright: © 2025 Gou, Chen, Huang, Ning, Gu, Duan, Du, Nan and Yuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yi Nan, Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, Ningxia Hui Region, China
    Ling Yuan, School of Pharmacy, Ningxia Medical University, Yinchuan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.