Case Report : Giant Dedifferentiated Retroperitoneal Liposarcoma, an extremely rare case

Huey Bing Chua ¹ Rizuana Iqbal Hussain ² Nordashima Abd Shukor ³ Fam Xeng Inn ^1*

• ¹ Department of Surgery, Hospital Chancellor Tuanku Muhriz, National University of Malaysia, Cheras, Kuala Lumpur, Malaysia
• ² Department of Radiology, Faculty of Medicine, National University of Malaysia, Cheras, Kuala Lumpur, Malaysia
• ³ Department of Pathology, Faculty of Medicine, National University of Malaysia, Wilayah Persekutuan, Kuala Lumpur, Malaysia

Retroperitoneal liposarcoma, especially dedifferentiated liposarcoma (DDL), is a rare tumor type primarily affecting middle-aged and older adults in the retroperitoneum or proximal extremities. This case report highlights an exceptionally large retroperitoneal DDL that had enveloped the entire right kidney and had adhered to nearby tissues.Diagnosing retroperitoneal liposarcoma is challenging due to its asymptomatic nature until it reaches a substantial size. Imaging, particularly contrast-enhanced computed tomography (CECT), play a vital role in diagnosis, staging, and preoperative planning. Surgical resection, with the goal of R0 resection, remains the cornerstone of treatment, albeit challenging due to tumor location. First-line treatment for advanced DDL involves anthracycline-based therapy. Eribulin and pazopanib show promise in second-line treatment. Ongoing clinical trials suggest a shift towards multimodal therapy.This case report is reporting the largest retroperitoneal liposarcoma, underscores the complexity of managing retroperitoneal DDL.