Desmoid-type fibromatosis of the breast: A case report and literature review

Zijun Zhao ¹ Qingyao Shang ¹ Chenxuan Yang ¹ Jiaxiang Liu ¹ Shanqing Liu ² Xiaoqian Li ³ Xiyu Kang ¹ Jiaxian Yue ¹ Xin Wang ^1* Xiang Wang ¹

• ¹ Department of Breast Surgery, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Beijing Municipality, China
• ² Department of Breast Disease, Henan Provincial Cancer Hospital, Zhengzhou, Henan Province, China
• ³ Department of General Surgery, Huairou Teaching Hospital, Capital Medical University, China, China

Breast desmoid-type fibromatosis (BDF) is a rare tumor predominated by mesenchymal cells. It has a high recurrence rate though distal metastasis is uncommon. It resembles breast cancer clinically and histological pathology is the only approach to a confirmed diagnosis. Comprehensive and individualized treatments were recommended for BDF patients. Here we presented a case of BDF secondary to primary breast carcinoma in our center. A 47-year-old female complained of a large mass in her left breast for 2.5 months. She has a past history of left breast carcinoma with a failure of surgical and systemic intervention. Despite an active re-operation, she still suffered from disease progression with a bad prognosis. After our report, the clinicopathological traits, differential diagnosis of BDF and current recommendation of management were discussed. This case report aimed to make a clear recognition of this rare and aggressive disease and elaborate up-to-date treatment recommendations. More effective drugs and larger-sample clinical studies are encouraged for better management of refractory and progressive BDF.