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CASE REPORT article
Front. Oncol.
Sec. Hematologic Malignancies
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1480661
18F-FDG PET/CT in the Diagnosis and Treatment of Atypical Extensive Skin Lesions in Extranodal NK/T-cell Lymphoma, Nasal Type (ENKTCL-NT): A Case Report
Provisionally accepted- Taihe Hospital, Hubei University of Medicine, Shiyan, China
We report a case of a 60-year-old male who developed scattered erythema and papules on his left upper limb without any apparent cause six months ago. Initially, the patient underwent evaluations for various dermatological conditions, including eczema and psoriasis, while also being assessed for potential malignancies such as cutaneous lymphoma or sarcoidosis, but no definitive diagnosis was made. Over time, the patient's symptoms progressed, presenting as generalized erythema, papules, localized itching, and pain. Histopathological examination of the lesions diagnosed it as extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT). Subsequently, the patient was referred for staging via 18 F-FDG PET/CT, which revealed a widespread pattern of metabolically active lesions primarily affecting the skin and subcutaneous tissue of the limbs and buttocks. The patient received sequential treatment with P-GEMOX (gemcitabine, oxaliplatin, and Pegaspargase) and underwent clinical examination and follow-up whole-body 18 F-FDG PET/CT after six treatment cycles. The posttreatment PET/CT showed no abnormal 18 F-FDG uptake in the nasal cavity or skin, confirming clinical complete remission. Our case highlights the significant role of 18 F-FDG PET/CT in the clinical practice of ENKTCL-NT for initial staging and treatment response assessment. 1 metabolically active lesions primarily affecting the skin and 36 subcutaneous tissue of the limbs and buttocks.
Keywords: Lymphoma, Nasal type, 18 F-FDG, PET/CT, therapy
Received: 14 Aug 2024; Accepted: 10 Mar 2025.
Copyright: © 2025 Liu and Pei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xu-Sheng Liu, Taihe Hospital, Hubei University of Medicine, Shiyan, China
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