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CASE REPORT article
Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1477848
Case Report: Neurolymphomatosis of the Peripheral Nerve as a Presentation of Relapsed Pediatric High Grade B cell Lymphoma
Provisionally accepted
Evelyn Ruoyun Lu 1,2
Wai Lan Yeung 1
Jeffrey Ping Wa Yau 1
King Sun Chu 3 Elaine Yee Ling Kan 4
Alan Kwok Shing Chiang 1,2*- 1 Department of Pediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Kowloon, Hong Kong, SAR China
- 2 Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Pokfulam, Hong Kong, SAR China
- 3 Department of Nuclear Medicine, Queen Elizabeth Hospital (QEH), Kowloon, Hong Kong, SAR China
- 4 Department of Radiology, Hong Kong Children's Hospital, Kowloon, Hong Kong, SAR China
Neurolymphomatosis (NL) of the peripheral nerve in pediatrics has never been reported, and ultrasonography (USG) as an investigation modality is rarely used. We report a case of an 11-year-old male with stage 4 mature high grade B cell lymphoma who presented with a two-week history of right ulnar neuropathy and left sciatic neuropathy one month after the completion of frontline chemotherapy. This case report illustrates the rare presentation of NL in lymphoma relapse and hopes to emphasize how early identification of this diagnosis and timely treatment are essential. Moreover, this case points out how USG, in the context of palpable mass and localized neurological signs, could facilitate a diagnosis of NL.
Keywords: Neurolymphomatosis, peripheral neuropathy, High grade B cell lymphoma, Neuropathy, Pediatric lymphoma
Received: 06 Jan 2025; Accepted: 01 Apr 2025.
Copyright: © 2025 Lu, Yeung, Yau, Chu, Kan and Chiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Alan Kwok Shing Chiang, Department of Pediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Kowloon, Hong Kong, SAR China
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