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MINI REVIEW article

Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1475153
This article is part of the Research Topic Use of Radiation Therapy for Hematological Malignancies View all 3 articles

Treatment of Primary Esophageal Lymphomas: A Review

Provisionally accepted
Joe El Khoury Joe El Khoury 1Remy Daou Remy Daou 1Neal Kim Neal Kim 2*Josiane Bou Eid Josiane Bou Eid 1Brandon Imber Brandon Imber 2Joachim Yahalom Joachim Yahalom 2Carla Hajj Carla Hajj 2
  • 1 Saint Joseph University, Beirut, Beirut, Lebanon
  • 2 Memorial Sloan Kettering Cancer Center, New York, United States

The final, formatted version of the article will be published soon.

    Primary esophageal lymphoma is a rare malignancy that is difficult to diagnose and treat. While there have been significant advances in understanding the pathogenesis, clinical features, and treatment options, there is a lack of consensus on the most effective treatment approach. This literature review provides a comprehensive overview of the use of available treatment options for primary esophageal lymphoma, including surgery, radiotherapy, and chemotherapy. The review also highlights the current knowledge gaps that need to be addressed through further research. While no single treatment modality has emerged as a clear front-runner, a combination of these treatments may be the most effective approach in managing primary esophageal lymphoma, tailored to the histological subtypes.

    Keywords: Esophageal lymphoma, DLBCL, follicular lymphoma, radiation treatment, MALT lymphoma

    Received: 02 Aug 2024; Accepted: 17 Jan 2025.

    Copyright: © 2025 El Khoury, Daou, Kim, Bou Eid, Imber, Yahalom and Hajj. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Neal Kim, Memorial Sloan Kettering Cancer Center, New York, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.