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CASE REPORT article

Front. Oncol.
Sec. Surgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1474931

A case report of breast Rosai-Dorfman disease and a literature review

Provisionally accepted
Yuan Lin Yuan Lin 1Ya-Wen Wang Ya-Wen Wang 1Li-Xin Li Li-Xin Li 1Zhong-Qi Qiao Zhong-Qi Qiao 2Xu Chen Xu Chen 1Yan-Duo Chen Yan-Duo Chen 3Can Liu Can Liu 1Kai Zhang Kai Zhang 1*
  • 1 Qilu Hospital, Shandong University, Jinan, China
  • 2 Department of General Surgery, Binzhou Second People's Hospital, Binzhou, Shandong, People’s Republic of China, Qilu Hospital, Shandong University, Jinan, China
  • 3 Department of Pediatric Surgery，Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People’s Republic of China, Jinan, China

The final, formatted version of the article will be published soon.

    Rosai-Dorfman disease (RDD) is a rare idiopathic histiocytoproliferative disease that usually affects the lymph nodes of the head and neck, but can also involve extranodal sites such as the skin, sinuses, and soft tissues. Breast RDD is exceedingly rare. It may be clinically and radiographically similar to neoplastic and non-neoplastic diseases. We report a case of breast RDD in a 68-year-old female patient and describe the clinical imaging and pathological features of the patient. The management of extranodal RDD is individualized, and there are no standardized guidelines for treatment. We highlight the importance of considering the diagnosis of extranodal breast RDD, and suggest that surgical resection is an effective way to treat this disease, particularly for single-focal breast lesions with RDD.

    Keywords: Breast, Rosai-Dorfman disease, Extranodal RDD, Pathological diagnosis, surgical treatment

    Received: 02 Aug 2024; Accepted: 28 Jan 2025.

    Copyright: © 2025 Lin, Wang, Li, Qiao, Chen, Chen, Liu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Kai Zhang, Qilu Hospital, Shandong University, Jinan, China

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