A case report of HER2-positive descending colon cancer with peritoneal metastasis and literature review

Human epidermal growth factor receptor 2 (HER2) is an anti-cancer drug target for colon cancer. Among patients with colorectal malignancy (colorectal cancer, CRC), those with HER2 mutations have a poor overall prognosis and a significantly increased drug resistance. In recent years, anti-HER2 therapeutic drugs have developed rapidly. According to several clinical studies and case reports, anti-HER2 therapy, as an emerging anti-cancer approach, plays a crucial role in the treatment of HER2-positive CRC patients. Here, we present a case of HER2-positive descending colon cancer with peritoneal metastasis. The patient is a 26-year-old male, diagnosed with malignant tumor of the descending colon with peritoneal metastasis in April 2020. After multiple treatment modalities, the disease progressed. After chemotherapy with Trastuzumab Deruxtecan (T-DXd/DS-8201), the metastatic foci significantly shrank, and after surgical resection, a tumor-free state (NED) was achieved. Up to now, the patient’s survival period has reached 56 months.

Introduction

CRC represents a prevalent malignant tumor within the gastrointestinal tract. Regrettably, a substantial portion of CRC cases are already in advanced stages upon detection. Presently, it holds the third position in terms of global incidence and the second position in mortality rates (1).

The treatment of early and mid-stage CRC mainly includes surgical resection, chemotherapy, radiotherapy, and immunotherapy, etc. The prognosis of the colorectal cancer (CRC) population is generally unfavorable. Treatment strategies are formulated based on specific biomarkers and clinical stratification, thereby determining the most appropriate regimens such as radiotherapy, chemotherapy, immunotherapy, and surgery in accordance with the individualized characteristics of patients (2). Tumor metastasis is a fatal factor for advanced CRC. Approximately 22% of CRC cases have metastasis at the time of onset, and 19% of cases will develop metachronous metastasis (3). Among them, peritoneal metastasis is an important metastasis route of CRC. In addition to traditional systemic and surgical treatments, targeted therapies have also been incorporated into the diagnosis and treatment of advanced metastatic CRC. Although the diagnosis and treatment level of advanced CRC has been continuously improving in recent years, the prognosis of advanced CRC is often unsatisfactory compared with that of early and mid-stage CRC. Most metastatic colorectal cancer (mCRC) is difficult to cure, but with the development of chemotherapy and targeted drugs, the survival rate of these patients has increased. And the new targeted HER2 treatment may bring hope for these special patients (4, 5).

HER2 plays an important role in normal biology and the carcinogenic process, and regulates cell proliferation, differentiation and migration through a variety of signal transduction pathways, such as mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and phosphatidylinositol 3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR), etc., to regulate cell functions (6). As a member of the receptor tyrosine kinase ERBB family, HER2 plays an important role in normal biology and tumorigenesis by driving multiple downstream signal transduction pathways, the most significant of which are the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase pathways. Abnormal activation of the MAPK pathway is one of the first key molecular alterations identified in CRC and usually represents an early step in tumorigenesis. Approximately 60% to 80% of colorectal adenocarcinomas have activating alterations in the MAPK pathway (7). In recent years, T-DXd has been gradually approved for application in a variety of HER2-positive solid tumors. T-DXd is a new type of anti-HER2 antibody-drug conjugate (ADC) composed of trastuzumab, a 4-peptide linker and an exatecan derivative. Studies have shown that many patients with HER2-positive solid tumors can benefit from T-DXd, and it has also shown significant effects in patients with HER2-positive CRC (8, 9).

Here, we report a patient with HER2-positive malignant tumor of the descending colon and peritoneal metastasis. At of the time of this manuscript submission, this patient has survived for 56 months. Currently, the patient is in a NED(No Evidence of Disease) state.

Case report

The patient, a 26-year-old young man, was admitted to the hospital on April 10, 2020, mainly due to “intermittent abdominal distension for more than 6 months and the discovery of descending colon cancer for 8 days”. Six months before admission, he had intermittent abdominal distension with intermittent bloody stool without cause. The bloody stool was dark red without mucus or pus and improved after self-symptomatic treatment. On April 2, 2020, the patient’s anus stopped exhausting and defecating. He was diagnosed with “intestinal obstruction” when visiting an outside hospital. After the intestinal stent was placed by endoscopy in the emergency department, the obstructive symptoms improved. Colonoscopy showed: a mass in the descending colon. Pathological examination of the biopsy showed: moderately differentiated adenocarcinoma of the descending colon. Thus, he was admitted to the hospital with “malignant tumor of the descending colon”. Since the onset of the disease, the patient was conscious with a good spirit, poor diet, good sleep, and had a weight loss of about 3kgs in the past 3 months. He had no previous history of special diseases and his mother has a personal history of thyroid malignancy. BMI: 23.53kg/m2, Body surface area: 1.78m2. Physical examination: The vital signs are stable. There were no enlarged lymph nodes or pedal edema on clinical examination. The remainder of the systemic examination was unremarkable. During the per-rectal examination (extending up to 7 centimeters from the anal verge), dark red blood was observed on the gloved finger.

Auxiliary examinations revealed a CEA level of 2.01 ng/ml and a CA199 level of < 2.0 U/ml. Electronic colonoscopy demonstrated that upon insertion of the endoscope to the junction of the descending and sigmoid colon, a significant amount of pasty feces was observed. At this junction, a new growth encircling the wall was detected, and the endoscope could not progress further due to luminal stenosis. Pathological examination of the colonoscopy specimen indicated moderately differentiated adenocarcinoma at the junction of the descending and sigmoid colon. Thoracic and abdominal CT scans exhibited no conspicuous abnormalities within the chest. However, a tumorous transformation near the splenic flexure of the descending colon was discerned. Additionally, multiple metastatic foci were detected in the greater omentum and abdominopelvic cavity, corresponding to the classification of (pT4bN0M1c, stage IV).

Diagnosis: Descending colon cancer; Incomplete intestinal obstruction; Peritoneal metastasis of malignant tumor.

After admission, the surgical contraindications were excluded. On April 16, 2020, laparoscopic left hemicolectomy + cytoreductive surgery + colostomy were performed. During the operation, it was seen that the tumor was located near the splenic flexure of the descending colon, penetrating the serous layer and invading the adjacent peritoneum. One metastatic lesion about 3×2 cm in size was seen in the greater omentum, and multiple metastatic lesions of different sizes were seen on the peritoneal membranes in the abdominal and pelvic cavities (PCI=7).

Postoperative pathological diagnosis: Left-sided colon cancer, ulcerative type, moderately differentiated tubular adenocarcinoma. The cancer tissue penetrated the entire layer of the intestinal wall. Cancer thrombus was seen in the blood vessels. The cancer tissue invaded the nerves. No cancer tissue was involved in the upper and lower resection ends and the lateral resection margin. No metastatic cancer was found in the lymph nodes (0/13). Additionally sent “Omental nodule, peritoneal nodule 1 and abdominal wall nodule 2”: All the submitted tissues were cancer nodules (Figures 1 and 2). FISH Results: The HER2/CEP17 ratio was determined to be 3.5, and the average HER2 copy number was measured at 8.2. These findings unequivocally indicate that the HER2 gene was amplified, thereby suggesting that the patient may potentially be a candidate for anti-HER2 targeted therapy. Additionally, the immunohistochemistry result from our hospital demonstrated that the patient was HER2 positive (3+) (Figure 3).

Figure 1

Figure 1. The resected left half of the colon and abdominal wall nodules.

Figure 2

Figure 2. Pathological examination after the first surgery 10*20 HE .

Figure 3

Figure 3. HER2 in situ hybridization photo.

After multiple rounds of discussions by the multidisciplinary team (MDT), the postoperative treatment for this patient is as follows:

After the surgery, intraperitoneal hyperthermic perfusion chemotherapy (Raltitrexed 5.3mg + Lobaplatin 53.4mg + Endostar 71.2mg) was performed. Subsequently, 11 cycles of Bev + mFOLFOX6 (L-OHP 150mg; CF 0.7g; 5-Fu 5g; Bev 340mg) treatment were given.PET-CT: After the surgery for left-sided colon cancer, multiple soft tissue nodular shadows were seen in the pelvic mesenteric space, with the largest one being approximately 12*11mm, accompanied by abnormal radioactive concentration, SUVmax 2.6 (Figure 4).

Figure 4

Figure 4. 2021-1-12PET-CT.

Subsequently, 10 cycles of BEV + FOLFIRI (CTP-11 320mg; CF 0.7g, 5-Fu 5g; Bev 340mg) chemotherapy combined with targeted therapy were administered. After a full abdominal MR on April 6, 2021, the efficacy evaluation showed a partial response (PR) of the tumor. A full abdominal MR was performed on July 2, 2021. The efficacy evaluation showed stable disease (SD). After the patient’s condition did not progress, 3 cycles of BEV + Capecitabine (Bev 340mg, Xeloda 124.6g) maintenance treatment were carried out. After a reexamination of MR on September 17, 2021, the efficacy evaluation showed disease progression (PD). The patient was advised to undergo anti-HER2 treatment, but due to the COVID-19 pandemic, the patient was unable to continue to participate in the subsequent treatment. On January 18, 2022, the abdominal CT evaluation showed PD. On March 15, 2022, the patient continued to come to the hospital for treatment and was given the first dose of Trastuzumab (544mg) + Pertuzumab (840mg), followed by 5 doses of Trastuzumab (408mg) + Pertuzumab (420mg) for a total of 6 cycles of treatment. On July 8, 2022, an abdominal CT was repeated to assess the partial response (PR). Subsequently, three cycles of trastuzumab combined with patuzumab were continuously administered. After the treatment, a reexamination of abdominal CT on October 9, 2022 showed PD in the efficacy evaluation. The treatment plan was adjusted to Regorafenib (160mg Po QD for 21 days) for 3 cycles. Abdominal CT showed SD in the efficacy evaluation. Regorafenib treatment was continued for 2 cycles. In the abdominal CT reexamination in February 2023, the efficacy evaluation was PD (Figure 5).

Figure 5

Figure 5. Abdominal CT in February 2023.

After the patient’s disease progressed after anti-HER2 treatment, T-DXd (435.2mg) was given for 6 cycles within the following 3 months. In the abdominal CT reexamination in May 2023, the efficacy evaluation was PR (Figure 6). In June 2023, the PET-CT indicated: No distant metastasis (Figure 7).

Figure 6

Figure 6. Three months after T-DXd treatment, abdominal CT in May 2023.

Figure 7

Figure 7. In June 2023, PET-CT.

After the anti-HER2 treatment with T-DXd was effective, on July 7, 2023, the operations of colostomy and resection of the metastasis beside the colostomy; partial rectus abdominis muscle resection; colostomy reversal; anterior resection of pelvic organs; para-aortic lymph node dissection; resection of the metastasis on the surface of the left psoas major muscle + partial psoas major muscle resection; appendectomy; ileal bladder substitution; ileostomy were performed. The postoperative pathological examination showed that a large amount of moderately differentiated tubular adenocarcinoma tissues were found in the rectal mucosa, the proper muscle layer, the perintestinal adipose tissue, the bladder wall mucosa, and the bladder wall muscle layer (Figures 8 and 9). According to the AICC/CAP pathological evaluation criteria after neoadjuvant chemotherapy: TRG: Grade 2 (Ryan classification: TRG Grade 1: Complete tumor regression, no residual tumor cells, only fibrous tissue is seen. TRG Grade 2: A small amount of residual tumor cells (single or small clusters of tumor cells). TRG Grade 3: A considerable amount of residual tumor cells, but less than fibrotic tissue. TRG Grade 4: Extensive residual tumor, no or a small amount of treatment response.). Metastatic carcinoma was found in the lesion on the surface of the psoas major muscle.

Figure 8

Figure 8. Postoperative pathological examination for the second time 10*20 HE.

Figure 9

Figure 9. The gross specimen of the surgical resection.

After 9 cycles of T-DXd (435.2mg) treatment after the surgery, the patient was evaluated as having No Evidence of Disease (NED). After comprehensive good physical condition, the ileostomy reversal operation was performed. There has been no recurrence or metastasis after the surgery. Currently, the patient is under regular follow-up.

Discussion

In the diagnosis and treatment process of this case, through multidisciplinary collaboration and the joint implementation of multiple measures, multiple rounds of anti-HER2 treatment were given after conventional chemotherapy, and the NED state was achieved through surgery after the condition was controlled. Especially the MDT discussions before each adjustment of the treatment plan to formulate individualized diagnosis and treatment plans for the patient, which is also the key factor for the patient’s ultimate long-term survival.

Peritoneal metastasis of CRC refers to the metastasis of cancer cells from the primary lesion to the peritoneum through factors such as the shedding of cancer cells and the peritoneal microenvironment. Peritoneal metastasis is the third most common metastasis route after liver and lung in CRC, and the prognosis is usually poor (10). Its treatment mainly includes cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS + HIPEC), the combination of systemic chemotherapy and intraperitoneal chemotherapy. Commonly used drugs include 5-fluorouracil, oxaliplatin, etc., as well as targeted therapy, etc (11). The treatment of peritoneal metastasis of CRC is a complex process that requires a multidisciplinary comprehensive diagnosis and treatment. Throughout the entire diagnosis and treatment process of this case, we have always adhered to the multidisciplinary comprehensive treatment model in order to formulate the best diagnosis and treatment plan for the patient. With the in-depth study of its pathogenesis and the continuous development of treatment techniques, the prognosis of these patients has been further improved.

The hyperthermic intraperitoneal perfusion therapy (HIPEC) used in this case also has a unique role in preventing peritoneal metastasis of CRC. HIPEC technology is an individualized diagnosis and treatment method formulated after an individual assessment in the abdominal cavity. It can improve the overall survival period of patients, improve the overall quality of life of patients, and reduce tumor recurrence and peritoneal metastasis caused by advanced (pT4) CRC (12). In a study by Qiu Cen et al. on the treatment of allogeneic CRC peritoneal metastasis model with raltitrexed intraperitoneal hyperthermia, it was shown that HIPEC does not cause serious adverse reactions and can effectively reduce the spread of cancer cells (13).

HER 2 is a proto-oncogene, and its genomic amplification or mutation is the main mechanism for the occurrence of some malignant tumors. HER 2 genomic amplification is commonly seen in breast cancer (BC) and gastric cancer (GC), with incidences of approximately 25% and 15% respectively; while it is relatively rare in CRC, with an incidence of approximately < 5% (14). Research data indicate that the objective response rate of HER 2 -positive CRC patients treated with trastuzumab + lapatinib or trastuzumab + pertuzumab respectively is 30% - 38% (15, 16). HER2 is not only a therapeutic target for CRC, but also a resistance mechanism for epidermal growth factor receptor (EGFR) targeted therapy (such as cetuximab and panitumumab) (17, 18). In this case, the tumor progressed after 7 - month treatment with trastuzumab + pertuzumab, which may be due to the development of drug resistance during this period. On August 11, 2022, the US FDA officially approved the listing of ENHERTU (code DS8201, fam - trastuzumab deruxtecan - nxki, Chinese name: fam - trastuzumab deruxtecan for injection) for adult patients with inoperable and treated HER2 - positive non - small cell lung cancer (NSCLC). T-DXd is a conjugate drug of HER2 antibody and irinotecan-based chemotherapy drug, belonging to the ADC-type drug category (19). The drug-to-antibody ratio of T-DXd reaches 100%, which enables T-DXd to deliver more effective molecules to the targeted tumor cells. The payload of T-DXd has a short half-life, which can minimize off-target toxicity. In addition, the connection point is cleaved by the highly expressed lysosomal enzymes in tumor cells, which can make T-DXd more stable in the systemic circulation and maintain a mild systemic toxicity (16, 20–22). In the Phase 2 DESTINY-Breast01 trial, the patients in the experiment had previously received two or more HER2-based anti-HER2 regimens, and T-DXd showed an objective response rate of 60.9% and a median progression-free survival of 16.4 months (23). Jose Perez et al.’s study also mentioned that T-DXd is expected to treat HER2 - positive solid tumors, including CRC, non-small cell lung cancer, etc (24). In the DESTINY-PanTumor02 study, it is used to evaluate the efficacy and safety of T-DXd (5.4 mg/kg, once every 3 weeks) in patients with locally advanced or metastatic solid tumors with HER2 expression (IHC 3+ or 2+). Among all patients, the ORR was 37.1% (n = 99; [95% CI, 31.3, 43.2]). This experiment shows that T-DXd not only provides durable clinical benefits in a variety of HER2 - expressing solid tumors, but also the greatest benefit can be observed in the IHC 3+ patient population (8). In the field of CRC, the DESTINY-CRC01 study has brought a new therapeutic drug for HER2 - positive CRC. In this study, 86 patients were randomly divided into three cohorts according to the HER2 expression situation. The results showed that T-DXd not only showed excellent efficacy in the refractory patient population, but also its safety and tolerability were within the controllable range. In particular, T-DXd showed an ORR of 45.3% and a median OS of 15.5 months in cohort A, which provides a new treatment option for HER2 - positive mCRC patients (25). The DESTINY-CRC02 study confirmed that T-DXd is effective for HER2 + mCRC patients at doses of 5.4 and 6.4 mg/kg. The 5.4 mg/kg dose can achieve better results in this population (11). In the DS8201 - A - J101 study initiated in 2015, the researchers evaluated the safety and tolerability of T-DXd in advanced solid tumors with HER 2 - positive. The dose escalation part of the study determined 5.4 mg/kg or 6.4 mg/kg as the recommended dose (26). While T-DXd has shown excellent therapeutic effects, researchers have also conducted corresponding studies on the adverse reactions after its use. Common complications after the use of T-DXd: interstitial lung disease (including pneumonia), cardiotoxicity, neutropenia and left ventricular dysfunction. Other important common adverse reactions include nausea, fatigue, vomiting, hair loss, constipation, loss of appetite, anemia, diarrhea and thrombocytopenia, etc., but the overall side effects are minial (27). Therefore, the application of T-DXd is safe and reliable. Based on the above studies, we used T - DXd in the treatment process of this case, and after multiple rounds of treatment, the patient’s tumor significantly shrank and the pathological regression grade reached TRG: Grade 2.

Conclusion

This article shares the diagnosis, treatment process and reflection of a patient with advanced malignant tumor of HER-2 positive descending colon cancer with peritoneal metastasis. After a clear diagnosis of the tumor in this case, the patient survived for a long time after surgery, HIPEC, systemic chemotherapy, and various targeted therapies, and achieved the No Evidence of Disease state after tumor cytoreductive surgery again.

In summary, the patient in this case achieved the NED state after multiple rounds of treatment and was able to survive for a long time, which is inseparably related to the implementation of MDT, relatively standardized systemic treatment, the application of anti-HER-2 drugs, the continuous progress of surgical techniques, and the patient’s perseverance.

Data availability statement

The original contributions presented in the study are included in the article/supplementary material. Further inquiries can be directed to the corresponding author.

Ethics statement

The manuscript presents research on animals that do not require ethical approval for their study. Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.

Author contributions

YL: Writing – original draft, Writing – review & editing, Methodology, Supervision. ZQ: Writing – original draft. wd: Conceptualization, Data curation, Investigation, Methodology, Supervision, Writing – review & editing. CZ: Data curation, Investigation, Writing – review & editing. JZ: Data curation, Writing – review & editing. YN: Data curation, Methodology, Writing – review & editing. BD: Data curation, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing.

Funding

The author(s) declare that financial support was received for the research and/or publication of this article. This study was financially supported by the following projects: Gansu Province Health and Wellness Industry Scientific Research Project (Project No. GSWSHL2020-17); Lanzhou Municipal Science and Technology Program Project (Project No. 2022-ZD-47; 2022-5-51; 2023-2-102).

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

References

1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. (2021) 71:209–49. doi: 10.3322/caac.21660

PubMed Abstract | Crossref Full Text | Google Scholar

2. Dekker E, Tanis PJ, Vleugels JLA, Kasi PM, Wallace MB. Colorectal cancer. Lancet. (2019) 394:1467–80. doi: 10.1016/S0140-6736(19)32319-0

PubMed Abstract | Crossref Full Text | Google Scholar

3. Väyrynen V, Wirta EV, Seppälä T, Sihvo E, Mecklin JP, Vasala K, et al. Incidence and management of patients with colorectal cancer and synchronous and metachronous colorectal metastases: a population-based study. BJS Open. (2020) 4:685–92. doi: 10.1002/bjs5.50299

PubMed Abstract | Crossref Full Text | Google Scholar

4. Hernandez Dominguez O, Yilmaz S, Steele SR. Stage IV colorectal cancer management and treatment. J Clin Med. (2023) 12:2072. doi: 10.3390/jcm12052072

PubMed Abstract | Crossref Full Text | Google Scholar

5. Gaye E, Penel N, Lebellec L. Novel treatment approaches for HER2 positive solid tumors (excluding breast cancer). Curr Opin Oncol. (2022) 34:570–4. doi: 10.1097/CCO.0000000000000873

PubMed Abstract | Crossref Full Text | Google Scholar

6. Roy-Chowdhuri S, Davies KD, Ritterhouse LL, Snow AN. ERBB2 (HER2) alterations in colorectal cancer. J Mol Diagn. (2022) 24:1064–6. doi: 10.1016/j.jmoldx.2022.07.001

PubMed Abstract | Crossref Full Text | Google Scholar

7. Seo AN, Kwak Y, Kim DW, Kang SB, Choe G, Kim WH, et al. HER2 status in colorectal cancer: its clinical significance and the relationship between HER2 gene amplification and expression. PloS One. (2014) 9:e98528. doi: 10.1371/journal.pone.0098528

PubMed Abstract | Crossref Full Text | Google Scholar

8. Meric-Bernstam F, Makker V, Oaknin A, Oh DY, Banerjee S, González-Martín A, et al. Efficacy and safety of trastuzumab deruxtecan in patients with HER2-expressing solid tumors: primary results from the DESTINY-panTumor02 phase II trial. J Clin Oncol. (2024) 42:47–58. doi: 10.1200/JCO.23.02005

PubMed Abstract | Crossref Full Text | Google Scholar

9. Smit EF, Felip E, Uprety D, Nagasaka M, Nakagawa K, Paz-Ares Rodríguez L, et al. Trastuzumab deruxtecan in patients with metastatic non-small-cell lung cancer (DESTINY-Lung01): primary results of the HER2-overexpressing cohorts from a single-arm, phase 2 trial. Lancet Oncol. (2024) 25:439–54. doi: 10.1016/S1470-2045(24)00064-0

PubMed Abstract | Crossref Full Text | Google Scholar

10. Xue L, Hyman NH, Turaga KK, Eng OS. Peritoneal metastases in colorectal cancer: biology and barriers. J Gastrointest Surg. (2020) 24:720–7. doi: 10.1007/s11605-019-04441-4

PubMed Abstract | Crossref Full Text | Google Scholar

11. Raghav KPS, Siena S, Takashima A, Kato T, Eynde MVD, Bartolomeo MD, et al. Trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2-overexpressing/amplified (HER2+) metastatic colorectal cancer (mCRC): primary results from the multicenter, randomized, phase 2 DESTINY-CRC02 study. J Clin Oncol. (2023) 41:3501–1. doi: 10.1200/JCO.2023.41.16_suppl.3501

Crossref Full Text | Google Scholar

12. Yan TD, Deraco M, Baratti D, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal surface Malignancy: expert consensus statements. Lancet Oncol. (2021) 22:e119–30.

PubMed Abstract | Google Scholar

13. Ammerata G, Filippo R, Laface C, Memeo R, Solaini L, Cavaliere D, et al. Hyperthermic intraperitoneal chemotherapy and colorectal cancer: From physiology to surgery. World J Clin Cases. (2022) 10:10852–61. doi: 10.12998/wjcc.v10.i30.10852

PubMed Abstract | Crossref Full Text | Google Scholar

14. Qiu C, Li Y, Liang X, Qi Y, Chen Y, Meng X, et al. A study of peritoneal metastatic xenograft model of colorectal cancer in the treatment of hyperthermic intraperitoneal chemotherapy with Raltitrexed. BioMed Pharmacother. (2017) 92:149–56. doi: 10.1016/j.biopha.2017.04.053

PubMed Abstract | Crossref Full Text | Google Scholar

15. Takegawa N, Yonesaka K. HER2 as an emerging oncotarget for colorectal cancer treatment after failure of anti-epidermal growth factor receptor therapy. Clin Colorectal Cancer. (2017) 16:247–51. doi: 10.1016/j.clcc.2017.03.001

PubMed Abstract | Crossref Full Text | Google Scholar

16. Sartore-Bianchi A, Trusolino L, Martino C, Bencardino K. Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial. Lancet Oncol. (2016) 17:738–46. doi: 10.1016/S1470-2045(16)00150-9

PubMed Abstract | Crossref Full Text | Google Scholar

17. Hurwitz H, Raghav KPS, Burris HA, Kurzrock R, John D, et al. Pertuzumab + trastuzumab for HER2-amplified/overexpressed metastatic colorectal cancer (mCRC): Interim data from MyPathway. J Clin Oncol. (2017) 35:676–6. doi: 10.1200/JCO.2017.35.4_suppl.676

Crossref Full Text | Google Scholar

18. Richman SD, Southward K, Chambers P, Kennecke HF. HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trials. J Pathol. (2016) 238:562–70. doi: 10.1002/path.4679

PubMed Abstract | Crossref Full Text | Google Scholar

19. Barry GS, Cheang MC, Chang HHL, Bencardino K, Lonardi S, Bergamo , et al. Genomic markers of panitumumab resistance including ERBB2/HER2 in a phase II study of KRAS wild-type (wt) metastatic colorectal cancer (mCRC). Oncotarget. (2016) 7:18953–64. doi: 10.18632/oncotarget.8006

PubMed Abstract | Crossref Full Text | Google Scholar

20. Nakada T, Sugihara K, Jikoh T, Abe Y, Agatsuma T, et al. The latest research and development into the antibody-drug conjugate, [fam-] trastuzumab deruxtecan (DS-8201a), for HER2 cancer therapy. Chem Pharm Bull. (2019) 67:173–85. doi: 10.1248/cpb.c18-00744

PubMed Abstract | Crossref Full Text | Google Scholar

21. Ogitani Y, Yamaguchi J, Ishii C, Hirai T, Atsumi R, Morita K, et al. Abstract A145: DS-8201a, a novel HER2-targeting ADC with a novel DNA topoisomerase I inhibitor, demonstrates a potent anti-tumor efficacy with differentiation from T-DM1 in preclinical studies. (2015).

Google Scholar

22. Nagai Y, Oitate M, Shiozawa H, Ando . Comprehensive Preclinical Pharmacokinetic Evaluations of Trastuzumab Deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate, in Cynomolgus Monkeys. Xenobiotica. (2018). doi: 10.1080/00498254.2018.1531158

PubMed Abstract | Crossref Full Text | Google Scholar

23. Lee J, Park YH. Trastuzumab deruxtecan for HER2+ advanced breast cancer. Future Oncol. (2022) 18:7–19. doi: 10.2217/fon-2021-0550

PubMed Abstract | Crossref Full Text | Google Scholar

24. Perez J, Garrigós L, Gion M, Jnne PA, Cortés J. Trastuzumab deruxtecan in HER2-positive metastatic breast cancer and beyond. Expert Opin Biol Ther. (2021) 21:811–24. doi: 10.1080/14712598.2021.1890710

PubMed Abstract | Crossref Full Text | Google Scholar

25. Yoshino T, Di Bartolomeo M, Raghav K, Masuishi T, Loupakis F, Kawakami H. Final results of DESTINY-CRC01 investigating trastuzumab deruxtecan in patients with HER2-expressing metastatic colorectal cancer. Nat Commun. (2023) 14:3332. doi: 10.1038/s41467-023-38032-4

PubMed Abstract | Crossref Full Text | Google Scholar

26. Ogitani Y, Hagihara K, Oitate M, Naito H, Agatsuma T. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. (2016) 107:1039–46. doi: 10.1111/cas.12966

PubMed Abstract | Crossref Full Text | Google Scholar

27. Swain SM, Nishino M, Lancaster LH, Li BT, Nicholson AG, Bartholmai BJ. Multidisciplinary clinical guidance on trastuzumab deruxtecan (T-DXd)-related interstitial lung disease/pneumonitis-Focus on proactive monitoring, diagnosis, and management. Cancer Treat Rev. (2022) 106:102378. doi: 10.1016/j.ctrv.2022.102378

PubMed Abstract | Crossref Full Text | Google Scholar