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CASE REPORT article

Front. Oncol.
Sec. Thoracic Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1469072
This article is part of the Research Topic Therapeutic Mechanism of Osteosarcoma View all 9 articles

Costal Chondrosarcoma in a Woman with Hereditary Multiple Exostoses -A Case Report

Provisionally accepted
Ze Yang Ze Yang Kaiqiang Wang Kaiqiang Wang Jiangtao Pu Jiangtao Pu *
  • Department of Thoracic Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China

The final, formatted version of the article will be published soon.

    In this report, we present a case of a 32-year-old female previously diagnosed with hereditary multiple exostoses(HME) who was incidentally found to have an asymptomatic anterior mediastinal mass during a routine examination. Computed tomography imaging revealed a well-defined mass measuring approximately 2.3 cm x 4.0 cm x 4.7 cm in the anterior mediastinum with multiple nodular areas of high density within. The mass caused compression and narrowing of the right ventricle. The patient subsequently underwent intralesional resection of the tumor, and histopathological examination confirmed a diagnosis of well-differentiated chondrosarcoma. Given the patient's medical history, the chondrosarcoma was suspected to have originated from malignant transformation of a rib osteochondroma. The patient received adjuvant radiotherapy postoperatively and has been followed up for one year with no evidence of recurrence. This case reports a highly rare costal chondrosarcoma secondary to hereditary multiple exostoses, located in the anterior mediastinum and compressing the right ventricle. To our knowledge, this is the first reported case of costal chondrosarcoma secondary to HME occurring in the anterior mediastinum, which requires differentiation from other common anterior mediastinal tumors.

    Keywords: Hereditary Multiple Exostoses 1, Malignant Conversion 2, Costal Chondrosarcoma 3, Mediastinal Tumor 4, Treatment5

    Received: 23 Jul 2024; Accepted: 30 Jan 2025.

    Copyright: © 2025 Yang, Wang and Pu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jiangtao Pu, Department of Thoracic Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China

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