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CASE REPORT article

Front. Oncol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1465645
This article is part of the Research Topic Precision Therapeutics in Rare Cancers: Targeting Tumor Microenvironment and Biomarker-Driven Approaches View all articles

Long term survival following cryoablation with adjuvant Toripalimab for anorectal malignant melanoma: A case report

Provisionally accepted
Xuejun Jiang Xuejun Jiang *Zujin Ji Zujin Ji Fangjun Yuan Fangjun Yuan Xinyi Lei Xinyi Lei Peng Li Peng Li Yong Yang Yong Yang
  • Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, China

The final, formatted version of the article will be published soon.

    Background: Anorectal malignant melanoma is a rare subtype of melanoma with a poor prognosis. Despite this, some patients decline Miles' operation due to the sigmoid colostomies that follow abdominoperineal resections in cases of anorectal malignant melanoma.Case report: We report the case of an 80-year-old woman diagnosed with anorectal malignant melanoma who underwent cryosurgery accompanied by adjuvant PD-1 therapy to maintain anal sphincter function. The results indicated that we successfully achieved the goal of sphincter preservation and therapeutic efficacy. The patient derived significant benefits from the cryoablation treatment.Conclusions: Ultrasound-guided trans-anal cryoablation, when combined with adjuvant PD-1 therapy, offers a novel treatment approach for patients with anorectal malignant melanoma. Our results have confirmed the advantages of this treatment regimen, particularly for those desiring to retain anal sphincter function. Further studies are required to substantiate the efficacy of ultrasound-guided trans-anal cryoablation with adjuvant Toripalimab and to elucidate its underlying mechanisms.

    Keywords: Anorectal malignant melanoma, Cryosurgery, Sphincter preservation, case report, Toripalimab, PD-1

    Received: 16 Jul 2024; Accepted: 08 Jan 2025.

    Copyright: © 2025 Jiang, Ji, Yuan, Lei, Li and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xuejun Jiang, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, China

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