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REVIEW article

Front. Oncol.
Sec. Cancer Metabolism
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1464914

The role of ubiquitination and deubiquitination in cancer lipid metabolism

Provisionally accepted
Yongkang Xu Yongkang Xu 1Jiayu Zeng Jiayu Zeng 2min fu min fu 1Ye Mao Ye Mao 1kan liu kan liu 1si tao si tao 1Jianbing Wu Jianbing Wu 1*
  • 1 Second Affiliated Hospital of Nanchang University, Nanchang, China
  • 2 Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi Province, China

The final, formatted version of the article will be published soon.

    The ubiquitin-proteasome system (UPS) is one of the main degradation systems within cells, catalyzing the tagging of proteins for degradation by ubiquitin molecules, which are then recognized and degraded by the proteasome. Lipid metabolism plays a crucial role in cellular energy metabolism and is closely associated with the occurrence and development of cancers. Recent research indicates that cancer lipid metabolism is regulated by intracellular proteins, including ubiquitination modifications. This review will explore the role of ubiquitination in regulating cancer lipid metabolism, summarize the latest research progress, and propose potential therapeutic strategies.

    Keywords: Ubiquitination, deubiquitination, Cancer, Lipid, Metabolism

    Received: 15 Jul 2024; Accepted: 07 Jan 2025.

    Copyright: © 2025 Xu, Zeng, fu, Mao, liu, tao and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jianbing Wu, Second Affiliated Hospital of Nanchang University, Nanchang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.