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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1450054
Deep cervical stromal invasion predicts poor prognosis in patients with stage II endometrioid endometrial cancer: a two-centered retrospective study
Provisionally accepted- 1 Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China
- 2 Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, Shanghai Municipality, China
- 3 Department of Oncology, Shanghai Medical College of Fudan University, Shanghai, Shanghai, China
- 4 Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China
Objective: To evaluate the impact of depth of cervical stromal invasion (CSI) on the prognosis of International Federation of Gynecology and Obstetrics (FIGO) stage II endometrioid endometrial cancer (EEC).Methods: Patients with FIGO stage II EEC confirmed by postoperative histopathology and consecutively admitted to the Obstetrics and Gynecology Hospital of Fudan University and Fudan University Shanghai Cancer Center between 2008 and 2017 were included in this study and reviewed retrospectively.Results: Two hundred and ninety-seven patients were included in this study. There were 253 (253/297, 85.2%）patients with superficial (<50%) and 44 (44/297, 14.8%) cases with deep (≥50%) CSI. The median follow-up time was 75.0 months (range: 5-175 months). Patients in the ≥50% CSI group had a poorer prognosis compared to the <50% CSI group (recurrence-free survival [RFS]: adjusted hazard ratio [aHR] = 6.077, 95% Confidence Interval [CI]: 2.275-16.236, disease-specific survival [DSS]: aHR = 7.259, 95% CI: 2.546-20.695,). Deep CSI was an independent predictor of local recurrence (aHR = 5.819, 95% CI: 1.856-18.243). Post operative external beam radiation therapy (EBRT) was correlated with a reduced risk of recurrence (aHR = 0.288, 95% CI: 0.097-0.859).Conclusion: Deep CSI is a poor prognostic factor for RFS and DSS in patients with FIGO stage II EEC. Postoperative EBRT can improve both RFS and DSS. Those findings imply that a detailed pathological report on the depth of CSI would be helpful in better understanding its impact on prognosis and selecting an appropriate postoperative treatment for the patient.
Keywords: Endometrial Neoplasms, Depth of Cervical Stromal Invasion, Radiotherapy, Adjuvant, recurrencefree survival, disease-specific survival
Received: 16 Jun 2024; Accepted: 10 Feb 2025.
Copyright: © 2025 Shao, Xue, Xu, Guan, Wang, Chen and Ren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yulan Ren, Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, Shanghai Municipality, China
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