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CASE REPORT article
Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 15 - 2025 |
doi: 10.3389/fonc.2025.1448374
Vestibular Scwhannomas and Papilledema without Hydrocephalus: a Case Report
Provisionally accepted- Unidad de Neurología y Neurocirugía, Hospital General de México, Mexico City, Mexico
Vestibular Schwannomas are frequent tumors of the cerebellopontine angle, classically presenting with cochlear and facial nerve alteration1,2. They tend to have histopathological and intratumoral degeneration seen on MRI, and can cause CSF obstruction with hydrocephalus with subsequent visual loss3. We present a case of bilateral visual loss from papilledema, with no history of hydrocephalus or increased intracranial pressure. CSF analysis showed isolated hyperproteinorrachia with no sign of infection or meningitis. This case report reviews current understanding of CSF physiology, including flow within the optic nerve sheath, which is a CSF reservoir with outflow through the complex glymphatic system.4 Multiple aquaporins regulate optic nerve CSF flow, responsible for the intense metabolic product washdown from the retinal apparatus5,6. Aquaporin activity is susceptible to up-regulation or down-regulation from CSF content, such as in the complexity of certain Vestibular Schwannomas, as seen on molecular and histopathological analysis in other studies7.
Keywords: Schwannoma, Papilledema, CSF (cerebrospinal fluid), glymphatic circulation, optic nerve sheath compartment
Received: 29 Jun 2024; Accepted: 07 Feb 2025.
Copyright: © 2025 Calderón-Moreno, Pérez Carrillo and Martinez-Manrique. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Noé Pérez Carrillo, Unidad de Neurología y Neurocirugía, Hospital General de México, Mexico City, Mexico
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