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ORIGINAL RESEARCH article
Front. Oncol.
Sec. Cancer Genetics
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1444874
Down-regulation of miR-125b by HPV16 E6 might promote cervical cancer progression through TAZ/TEAD
Provisionally accepted- Second Hospital of Shanxi Medical University, Taiyuan, China
compared to normal cervical tissue (P < 0.05). Functional assays using a miR-125b mimic revealed inhibited proliferation, migration, and invasion of SiHa cells along with enhanced apoptosis, concomitant with decreased expression of HPV16 E6, TAZ, and TEAD mRNA. Conversely, these effects were reversed upon introduction of a miR-125b inhibitor. Notably, overexpression of HPV16 E6 was associated with suppressed miR-125b expression (P < 0.05) and enhanced TAZ and TEAD expression (P < 0.05), as corroborated by western blot analysis.HPV E6 promotes the malignant progression of cervical cancer cells by downregulating miR-125b, which targets TAZ, thus regulating the Hippo pathway.Consequently, miR-125b emerges as a promising therapeutic target for HPV-induced cervical cancer.
Keywords: cervical cancer, Hippo pathway, HPV16 E6, miR-125b, TAZ
Received: 06 Jun 2024; Accepted: 26 Mar 2025.
Copyright: © 2025 Hou, Zhang, Wang, Cheng, Wang, Ji, Su and Hao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Min Hao, Second Hospital of Shanxi Medical University, Taiyuan, China
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