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CASE REPORT article

Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1444149
This article is part of the Research Topic The microbiome in surgery - friend or foe? View all 7 articles

Case Report: A Case Report and Literature Review on Spontaneous Bacterial Peritonitis Induced by Intestinal Barrier Damage in A Colorectal Cancer Patient with Malnutrition

Provisionally accepted
Peng Xu Peng Xu Sanbao Shi Sanbao Shi *Zhiyu Yu Zhiyu Yu Da Li Da Li *Cheng Zhang Cheng Zhang *
  • Department of General Surgery, Northern Theater Command, Shenyang, China

The final, formatted version of the article will be published soon.

    Background:Spontaneous bacterial peritonitis (SBP) is an infectious condition characterizing the presence of bacterial infection in the peritoneal fluid with no apparent source of infection within the abdomen. It is extremely rare for patients with malnutrition after colorectal cancer (CRC) surgery to develop SBP. This is the first ever case reported case of SBP resulting from intestinal barrier compromise in a patient with colorectal cancer with malnutrition.Case Summary:A 72-year-old woman with malnutrition was diagnosed with CRC, and following brief nutritional support, she underwent the laparoscopic-assisted radical right hemicolectomy. The patient was then diagnosed with peritonitis after the operation. An emergency laparotomy was performed, and the patient was finally diagnosed with SBP. The patient ultimately recovered following a series of appropriate postoperative supportive treatments.Conclusion:This case highlights the poor outcomes of short preoperative nutritional therapy in CRC patients with malnutrition. Further studies should investigate the role of the intestinal barrier function in the recovery of patients with CRC after surgery.

    Keywords: Spontaneous bacterial peritonitis, intestinal barrier, Malnutrition, colorectal cancer, Surgery

    Received: 06 Jun 2024; Accepted: 28 Jan 2025.

    Copyright: © 2025 Xu, Shi, Yu, Li and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Sanbao Shi, Department of General Surgery, Northern Theater Command, Shenyang, China
    Da Li, Department of General Surgery, Northern Theater Command, Shenyang, China
    Cheng Zhang, Department of General Surgery, Northern Theater Command, Shenyang, China

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