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SYSTEMATIC REVIEW article

Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1440105
This article is part of the Research Topic Cancer in People living with HIV/AIDS View all 6 articles

Patients with colorectal cancer combined with HIV had a worse overall survival after surgery: a meta-analysis

Provisionally accepted
Wen-Wen Yang Wen-Wen Yang 1Xiong Zhou Xiong Zhou 2Gan He Gan He 2*
  • 1 Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
  • 2 Yongchuan Hospital of Chongqing Medical University, Chongqing, China

The final, formatted version of the article will be published soon.

    The purpose of this current study was to find out whether human immunodeficiency virus (HIV) affected overall survival (OS) of colorectal cancer (CRC) patients after surgery. PubMed, Embase, the Cochrane Library, and CNKI were searched from inception to March 27, 2023 to find eligible studies. Eligible studies included CRC patients grouped by HIV status (HIV-positive and HIV-negative). Stata SE 16 was used for data analysis. A total of eight studies involving 2180 patients were enrolled in this study. After data analysis, there were significant differences in sex (OR=0.69, 95% CI=0.49 to 0.98, I 2 =22.6%, P=0.04<0.1), tumor grade (OR=6.61, 95% CI=2.36 to 18.49, I 2 =0.00%, P=0.00<0.1), and tumor location (OR=2.19, 95% CI=1.74 to 2.77, I 2 =0.04%, P=0.00<0.1) between the HIV and non-HIV groups. Furthermore, we found that HIV was associated with worse OS in CRC patients after surgery (HR=3.12, 95% CI=2.07 to 4.69, I 2 =52.51%, P=0.00<0.1). This study highlights that HIV is associated with significantly poorer OS in CRC patients after surgery, emphasizing the need for tailored postoperative management strategies for this vulnerable population. Future research should explore underlying mechanisms and potential interventions to improve outcomes for HIV-positive CRC patients.

    Keywords: HIV, colorectal cancer, Surgery, overall survival, Infection

    Received: 29 May 2024; Accepted: 10 Jan 2025.

    Copyright: © 2025 Yang, Zhou and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Gan He, Yongchuan Hospital of Chongqing Medical University, Chongqing, China

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