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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Thoracic Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1424682

Prognosis of nodal micrometastasis in resectable pN0 non-small cell lung cancer (NSCLC)

Provisionally accepted
Sophon Siwachat Sophon Siwachat 1Apichat Tantraworasin Apichat Tantraworasin 1*Nirush Lertprasertsuke Nirush Lertprasertsuke 2Somcharoen Saeteng Somcharoen Saeteng 1
  • 1 General Thoracic Surgery Unit, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
  • 2 Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

The final, formatted version of the article will be published soon.

    Background: Nodal micrometastasis (NMM) is the presence of a small cluster of tumor cells in a regional lymph node. However, the prognostic value of NMM in resectable NSCLC is still debated.Methods: This retrospective cohort study at Maharaj Nakorn Chiang Mai Hospital from 2006 to 2017 assesses the prognostic impact of nodal micrometastasis in resectable pN0 NSCLC patients, using immunohistochemistry staining for cytokeratin AE1/AE3, p53, and BerEp4.Patients are categorized into three groups: pN0 without nodal micrometastasis, pN0 with nodal micrometastasis, and pN+. Overall survival is the primary endpoint, with disease-free survival as the secondary endpoint.Results: Out of 225 patients, 98 had pathological N0 (pN0) status and 127 had pathological N positive (pN+) status. Among pN0 patients, nodal micrometastasis was found in 21 cases (21.43%), distributed as follows: 2 (2.04%) in hilar and interlobar regions (N1), 17 (17.35%) in the mediastinal region (N2), and 2 in both hilar and mediastinal regions (N1+N2) (2.04%).Univariable analysis revealed that male sex and the presence of tumor necrosis increased both the recurrence rate of lung cancer and the mortality rate, whereas larger tumor size, intra-tumoral vascular invasion, and pleural invasion were associated solely with cancer recurrence. However, multivariable analysis showed no statistically significant difference in disease-free survival and overall survival between pN0 patients with and without NMM, with hazard ratios of 0.98 (95% CI: 0.31-3.08, P=0.973) and 1.11 (95% CI: 0.23-5.42, P=0.900), respectively. Conclusion: Nodal micrometastasis was identified in 21.43% of pN0 resectable NSCLC patients.However, the benefits of NMM detection in resectable cases remain controversial due to conflicting results from retrospective studies. Larger prospective cohort studies are needed to better understand disease prognosis and inform treatment strategies.

    Keywords: Resectable non-small cell lung cancer, nodal micrometastasis, occult micrometastasis, Immunohistochemistry, prognosis

    Received: 28 Apr 2024; Accepted: 15 Jan 2025.

    Copyright: © 2025 Siwachat, Tantraworasin, Lertprasertsuke and Saeteng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Apichat Tantraworasin, General Thoracic Surgery Unit, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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