95% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
REVIEW article
Front. Oncol.
Sec. Breast Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1420350
Relationship between Breast Tissue Involution and Breast Cancer
Provisionally accepted- 1 Department of Breast Surgery, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China
- 2 Department of The First Clinical Medical School, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
Breast tissue involution is a process in which the epithelial tissue of the mammary gland gradually disappears with age. The relationship between breast tissue involvement and breast cancer (BC) has received increasing amounts of attention in recent years. Many scholars believe that breast tissue involution is a significant risk factor for BC. Breast imaging parameters, particularly mammographic density (MD), may indirectly reflect the degree of breast tissue involution, which may provide a solid basis for classifying priority screening groups for BC. This review explored the relationship between breast tissue involution and BC by providing an overview of breast tissue involution and elaborating on the association between MD and BC.Consistent with the results of other studies, women with complete breast tissue involution had a lower risk of BC, whereas women with a high MD had a relatively greater risk of BC.
Keywords: mammary gland, Breast involution, TDLU, breast density, breast cancer
Received: 20 Apr 2024; Accepted: 17 Mar 2025.
Copyright: © 2025 Li, Zhao, Lu, Ren, Han and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiangqi Li, Department of Breast Surgery, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.