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CASE REPORT article

Front. Oncol.
Sec. Genitourinary Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1410148

Case Report: Successful Treatment of Hyperbaric Oxygen for Radiation-Induced Hemorrhagic Cystitis in a 95-year-old Patient with Bladder Cancer

Provisionally accepted
Li Lin Li Lin 1,2Man He Man He 2Yanyan Zeng Yanyan Zeng 2Xiao-xiao Ni Xiao-xiao Ni 2Yequn Guo Yequn Guo 2Xiaojuan Xie Xiaojuan Xie 2Lingling Sun Lingling Sun 2Huai Huang Huai Huang 2*
  • 1 Guangzhou University of Chinese Medicine, Guangzhou, China
  • 2 Department of Hyperbaric Oxygen Medicine and Rehabilitation, General Hospital of Southern Theater Command of PLA, Guangzhou, China

The final, formatted version of the article will be published soon.

    Background: Severe radiation-induced hemorrhagic cystitis (RHC) may ultimately require radical cystectomy. High-quality clinical evidence exists regarding the impact of hyperbaric oxygen therapy (HBOT) on RHC. However, there is a lack of reported data addressing the applicability of HBOT in very elderly patients (over 90 years old) with severe bleeding necessitating multiple blood transfusions.The patient is a 95-year-old male who suffered from severe hematuria due to RHC after 33 sessions of radiotherapy for muscle-invasive bladder cancer (T2N0M0, stage: II). After a series of subsequent therapies that failed to control the hematuria, the patient received 196 HBOTs between

    Keywords: Hyperbaric oxygen therapy (HBOT), Bladder cancer, Radiation-induced hemorrhagic radiation cystitis, Late radiation cystitis, Hematuria, elderly patient

    Received: 24 May 2024; Accepted: 14 Jan 2025.

    Copyright: © 2025 Lin, He, Zeng, Ni, Guo, Xie, Sun and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Huai Huang, Department of Hyperbaric Oxygen Medicine and Rehabilitation, General Hospital of Southern Theater Command of PLA, Guangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.