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SYSTEMATIC REVIEW article

Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1404695
This article is part of the Research Topic Immune Checkpoint Inhibitors in Advanced Gastric and Esophageal Cancers View all 12 articles

Baseline (Derived) Neutrophil-lymphocyte Ratio Associated with Survival in Gastroesophageal Junction or Gastric Cancer Treated with ICIs

Provisionally accepted
Chong Jin Chong Jin 1*Chengyang Yu Chengyang Yu 2Hao Jiang Hao Jiang 1Liezhi Wang Liezhi Wang 1Zufu Jiang Zufu Jiang 1
  • 1 Taizhou Central Hospital, Taizhou, China
  • 2 Taizhou Cancer Hospital, Taizhou, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    Objective: We carried out the meta-analysis to determine the predictive value of baseline neutrophil to lymphocyte ratio (NLR) and derived neutrophil to lymphocyte ratio (dNLR) levels in patients with gastroesophageal junction or gastric cancer (GJGC) who underwent immune checkpoint inhibitor (ICI) treatment.Methods: Eligible articles were obtained through PubMed, the Cochrane Library, EMBASE, and Google Scholar, until April 15, 2023. The clinical outcomes evaluated in this study encompassed overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and disease control rate (DCR) Results: A total of 24 articles with 2221 patients were included in this meta-analysis.The pooled results demonstrated that patients with high NLR levels had significantly

    Keywords: immune checkpoint inhibitors, Gastroesophageal junction or gastric cancer, Neutrophil to lymphocyte ratio, Derived neutrophil to lymphocyte ratio, prognosis

    Received: 21 Mar 2024; Accepted: 06 Jan 2025.

    Copyright: © 2025 Jin, Yu, Jiang, Wang and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chong Jin, Taizhou Central Hospital, Taizhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.