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CASE REPORT article

Front. Oncol.
Sec. Radiation Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1367346

Intensity-modulated Radiotherapy Combined with Immunotherapy for Intramedullary Spinal Cord metastases of Lung Adenocarcinoma

Provisionally accepted
Yingying He Yingying He 1Wei Hu Wei Hu 2*Xie Fei Xie Fei 1Tianli He Tianli He 2Zhou Zhou Zhou Zhou 2Zhaohong Chen Zhaohong Chen 1Lixing Jiang Lixing Jiang 2
  • 1 Department of Oncology, People’s Hospital of Deyang City, Deyang, China
  • 2 Department of Radiation Oncology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

The final, formatted version of the article will be published soon.

    Intramedullary spinal cord metastases (ISCMs) are rare in clinical practice and their presentation is usually an unfavorable sign with a median overall survival (mOS) of 3-4 months after diagnosis. Due to their rarity, heterogeneity and rapid progression, clinicians have few satisfactory guidelines or optimal management for ISCMs. Herein, we share a clinical experience of intensity-modulated radiotherapy (IMRT) combined with immunotherapy (IO) for ISCMs from lung adenocarcinoma (LUAD) that achieved a relatively high quality of life for 10 months, which has not been previously reported.

    Keywords: intramedullary spinal cord metastases, Intestinal Obstruction, Intensitymodulated radiotherapy, Immunotherapy, Pneumonia

    Received: 08 Jan 2024; Accepted: 31 Jan 2025.

    Copyright: © 2025 He, Hu, Fei, He, Zhou, Chen and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wei Hu, Department of Radiation Oncology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.