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SYSTEMATIC REVIEW article
Front. Oncol.
Sec. Radiation Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1365966
Incidences of Pneumonitis Associated with the Combination of Radiotherapy and Immune Checkpoint Inhibitors in Lung Cancer: A Systematic Review and Meta-analysis
Provisionally accepted- First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, China
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Objective: Recently, the therapeutic effects of the combination of radiotherapy (RT) and immune checkpoint inhibitors (ICIs) on lung cancer (LC) have piqued the interest of the scientific community. Clinical trials have confirmed that RT and ICI therapy exert synergistic therapeutic effects. However, treatment with the RT-ICI combination can lead to the occurrence of pneumonitis, limiting the implementation of the treatment plan, decreasing the tumor control rate, and inducing immunosuppressive pneumonitis and radiation pneumonitis.Therefore, this study performed a systematic review and meta-analysis of pneumonitis prevalence among patients with LC who were treated with a combination of ICIs and chemoradiotherapy (CRT).
Keywords: Radiotherapy, immune checkpoint inhibitors, lung cancer, Systematic review, Meta-analysis
Received: 05 Jan 2024; Accepted: 31 Mar 2025.
Copyright: © 2025 Jing, Lingli, Chaomin, Wei, Yan, Dan and Ting. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jiang Ting, First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.