Skip to main content

CLINICAL TRIAL article

Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1533816

Changes in Gut Microbiota after Gastric Cancer Surgery: A prospective longitudinal study

Provisionally accepted
Yuhua He Yuhua He *Shi-Lin Gao Shi-Lin Gao Lili Jiang Lili Jiang *Jie Yang Jie Yang *
  • Colorectal Cancer Center, West China Hospital, Sichuan University/ West China School of Nursing, Sichuan University, Chengdu, Sichuan, China., Chengdu, China

The final, formatted version of the article will be published soon.

    Background: This study was designed to characterize gut microbiota changes of the patients being gastric cancer before and after the gastrectomy during their hospital staying periods.Methods: 16S rRNA gene sequencing was used to evaluate differences in gut microbiota among patient with gastric cancer before and after the gastrectomy by comparing gut microbiota α diversity, β diversity and structure composition at different taxonomic levels.2 Results: A total of 120 fecal specimens were collected from 60 patients. There was no significant difference in Chao1 index, Shannon index and Simpson index before and after gastrectomy (all P> 0.05). At the phylum level, the gut microbiota in the gastrectomy group showed less abundance of

    Keywords: surgery List of abbreviations GC: Gastric Cancer GI: Gastrointestinal RYGB: Roux-en-Y Gastric Bypass, gastric cancer, gastrointestinal tumour, Roux-en-Y, gut flora

    Received: 25 Nov 2024; Accepted: 27 Dec 2024.

    Copyright: © 2024 He, Gao, Jiang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yuhua He, Colorectal Cancer Center, West China Hospital, Sichuan University/ West China School of Nursing, Sichuan University, Chengdu, Sichuan, China., Chengdu, China
    Lili Jiang, Colorectal Cancer Center, West China Hospital, Sichuan University/ West China School of Nursing, Sichuan University, Chengdu, Sichuan, China., Chengdu, China
    Jie Yang, Colorectal Cancer Center, West China Hospital, Sichuan University/ West China School of Nursing, Sichuan University, Chengdu, Sichuan, China., Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.