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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Head and Neck Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1529136
This article is part of the Research Topic Pathophysiology and Therapeutic Strategies for Oral and Head and Neck Cancers View all articles

Retrospective Analysis of 1539 Nasopharyngeal Carcinoma Cases: Chemotherapy Should not Be Excluded for Non-Asian Patients with T1-2N1M0 Stage

Provisionally accepted
Xin-Yu Li Xin-Yu Li 1*Chang-Ying Zhong Chang-Ying Zhong 2*Hui-Xian Xu Hui-Xian Xu 3*
  • 1 Hunan Traditional Chinese Medical College, Zhuzhou, China
  • 2 Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Changsha, China
  • 3 The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China

The final, formatted version of the article will be published soon.

    Background: Many results suggested that chemotherapy can not provide survival benefit for stage II nasopharyngeal carcinoma. It remained unclear whether the efficacy of chemotherapy differed in non-Asian populations. Objective: It was designed to analyze the effect of chemotherapy for Asian and non-Asian patients with stage II nasopharyngeal carcinoma. Method: Patients were collected using the SEER program. The variables included age, sex, race, marital status, survival time, survival status, TNM stage, radiation and chemotherapy. Utilizing the Rstudio (version: 2024.4.1.748) and R (version: 4.4.1), backward elimination method was employed to screen the variables and multivariate Cox regression analyses was conducted on the screened variables. Kaplan-Meier method was utilized to analyse the survival of sub-stages and different races with T1-2N1M0 stage. The log-rank test was used for statistical analysis. Result: 1539 patients were collected. Chemotherapy was statistically significant, with a hazard ratio (HR) of 0.64, P=0.003 in stage II patients. The HR for radiation was 0.33, P<0.001. Chemotherapy didn't improve cancer-specific survival for patients with T2N0M0 stage. Asian and non-Asian races showed no difference in cancer-specific survival in T2N0M0 stage with HR of 1.85, P=0.13. For patients with T1-2N1M0 stage, chemotherapy improved cancer-specific survival with a HR of 0.53, P<0.001. No significant difference was in the Kaplan-Meier analysis between the two sub-stages (P=0.065). In T1-2N1M0 stage, multivariate Cox regression analysis for Asian race indicated that chemotherapy didn't improve cancer-specific survival with a HR of 0.64, P=0.190. For non-Asian Retrospective Analysis of 1539 Cases: Impact of Chemotherapy on Survival in Stage II Nasopharyngeal Carcinoma.

    Keywords: nasopharyngeal carcinoma, T1-2N1M0 stage, Stage II, chemotherapy, race

    Received: 16 Nov 2024; Accepted: 27 Dec 2024.

    Copyright: © 2024 Li, Zhong and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xin-Yu Li, Hunan Traditional Chinese Medical College, Zhuzhou, China
    Chang-Ying Zhong, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Changsha, China
    Hui-Xian Xu, The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China

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