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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Radiation Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1525926

Non melanoma skin cancer treated with hypofractionaded 192 -Ir contact brachitherapy: a single institution series

Provisionally accepted
Elisa Ciurlia Elisa Ciurlia 1Bianca Santo Bianca Santo 1,2*Maria Cristina Barba Maria Cristina Barba 1Elisa Cavalera Elisa Cavalera 1Paola De Franco Paola De Franco 1Sara De Matteis Sara De Matteis 1Giuseppe Di Paola Giuseppe Di Paola 1Angela Leone Angela Leone 1Antonella Papaleo Antonella Papaleo 1Dino Rubini Dino Rubini 3Donatella Russo Donatella Russo 1Giuseppe Rubini Giuseppe Rubini 4Angela Sardaro Angela Sardaro 1
  • 1 Radiation Oncology Unit, Dipartimento di Oncoematologia, Ospedale “Vito Fazzi”, Lecce, Italy, Lecce, Italy
  • 2 Oncology Hospital Vito Fazzi, Lecce, Italy
  • 3 Radiation Therapy Unit, Department of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli,, Napoli, Italy
  • 4 Nuclear Medicine Unit, Interdisciplinary Department of Medicine, University of Bari, Bari, Italy

The final, formatted version of the article will be published soon.

    Background:Non-melanoma skin carcinoma (NMSC) is the most common malignant tumour in the population, with a steadily increasing incidence due to an ageing population and sun exposure. The two main subtypes of NMSC are basal cell carcinoma(BCC) and squamous cell carcinoma(SCC). Therapeutic management of NMSC includes a variety of options such as surgery, radiotherapy, and topical or systemic treatments. High-dose fractionated contact brachytherapy (c-HDR-BRT) represents a viable therapeutic option for the treatment of NMSCs; Methods: At our Centre, we treated 39 patients with BCC or SCC, with a total of 46 lesions treated by c-HDR-BRT. The patients underwent two different radiotherapy schedules: 40 Gy in 4 fractions and 30 Gy in 3 fractions; Results: Two-year results show 100% local control (LC) and 100% disease-specific survival (DSS), indicating high efficacy of c-HDR-BRT in terms of tumour control. Furthermore, the observed toxicity profile was favourable, with not significant late toxicity; Conclusions:These results suggest that c-HDR-BRT represents a viable therapeutic alternative for NMSC, combining high oncological efficacy with an acceptable safety profile, while minimising the aesthetic and functional impact of therapy. Finally, the study emphasises the importance of personalisation of treatment, careful evaluation of individual cases in order to optimise the treatment approach in NMSC.Non-melanoma skin cancers (NMSC) represent a highly prevalent condition, predominantly affecting the elderly population. The increasing age of the general population, coupled with increased sun

    Keywords: Non-melanoma skin carcinoma, basal cell carcinoma, Squamous cell carcinoma, High-dose fractionated contact brachytherapy, personalisation of treatment

    Received: 10 Nov 2024; Accepted: 12 Dec 2024.

    Copyright: © 2024 Ciurlia, Santo, Barba, Cavalera, De Franco, De Matteis, Di Paola, Leone, Papaleo, Rubini, Russo, Rubini and Sardaro. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Bianca Santo, Oncology Hospital Vito Fazzi, Lecce, Italy

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