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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Gynecological Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1525601

HLA-DMB Correlates With Antitumor Immunity and an Improved Prognosis in Endometrial Carcinoma Tumors

Provisionally accepted
jiexian du jiexian du 1*xiaoyu xi xiaoyu xi 1xiaona zhang xiaona zhang 2jianxin tang jianxin tang 1xiumei fan xiumei fan 3
  • 1 Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
  • 2 Hengshui Fifth People's Hospital, Hengshui, Hebei Province, China
  • 3 Xingtai Central Hospital, Xingtai, Shandong, China

The final, formatted version of the article will be published soon.

    Endometrial Carcinoma(UCEC)is a prevalent malignant tumor within the female reproductive system. HLA-DMB, the beta chain of the non-classical MHC class II protein HLA-DM, has been implicated in the progression of various cancers. The expression of HLA-DMB at both mRNA and protein levels is significantly higher in UCEC tissues compared to normal tissues. Prognostic analyses indicate that increased expression of HLA-DMB correlates with improved patient prognosis, suggesting its potential as an independent prognostic factor for UCEC. Furthermore, in endometrial cancer, elevated levels of HLA-DMB are associated with higher immune infiltration scores and are closely related to various immune-enhancing factors. Mechanistically, HLA-DMB primarily participates in CD22-mediated regulation of B cell receptors (BCR), leading to BCR antigen activation and the production of second messengers. In our drug analysis, we identified several chemical agents associated with HLA-DMB, including cisplatin, dexamethasone, and ethinylestradiol. In conclusion, this study elucidates the function and underlying mechanisms of HLA-DMB in UCEC, providing a potential biomarker and target for immunotherapy in this disease.

    Keywords: endometrial carcinoma, prognosis, Immunohistochemistry, anti-tumor immunity, qPCR

    Received: 10 Nov 2024; Accepted: 20 Dec 2024.

    Copyright: © 2024 du, xi, zhang, tang and fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: jiexian du, Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.