Skip to main content

CASE REPORT article

Front. Oncol.
Sec. Thoracic Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1523104

A Rare Case of Chondrosarcoma-like Malignant Giant Cell Tumor in Adolescent Rib: Diagnostic Challenges and Treatment

Provisionally accepted
Zhuolin Qin Zhuolin Qin 1Longqian Li Longqian Li 1*Tao Jing Tao Jing 1,2Cheng Wang Cheng Wang 1,2*
  • 1 Lanzhou University, Lanzhou, China
  • 2 Lanzhou University Second Hospital, Lanzhou, Gansu Province, China

The final, formatted version of the article will be published soon.

    Chondrosarcoma-like malignant giant cell tumor (GCT) of the rib is an extremely rare and aggressive tumor, particularly in adolescents. This case report describes a 19-year-old female presenting with a GCT of the rib with chondrosarcomatous differentiation, highlighting the challenges posed by its unusual location and pathological complexity. Multidisciplinary diagnostic approaches, including advanced imaging, immunohistochemistry (IHC), and pathology, were essential for confirming the diagnosis. Key IHC markers such as Vimentin, SMA, and CD163, alongside genetic analysis excluding H3F3A mutations, guided the diagnostic process. The patient underwent successful surgical resection, achieving early recovery without adjuvant therapy. This report underscores the importance of early detection, precise pathological evaluation, and individualized surgical treatment for rare and high-risk tumors, emphasizing the need for long-term follow-up to monitor recurrence.

    Keywords: case report, Giant Cell Tumors, malignant, Rib, chondrosarcoma-like

    Received: 05 Nov 2024; Accepted: 24 Dec 2024.

    Copyright: © 2024 Qin, Li, Jing and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Longqian Li, Lanzhou University, Lanzhou, China
    Cheng Wang, Lanzhou University, Lanzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.