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CASE REPORT article

Front. Oncol.
Sec. Surgical Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1521253

Mass resection is a candidate treatment for uterine PEComas of uncertain malignant potential: A case report and literature review

Provisionally accepted
Haijuan Shi Haijuan Shi Yan Yin Yan Yin Shoujun Liang Shoujun Liang Chuanzhong Liu Chuanzhong Liu Yibao Huang Yibao Huang Liying Zhang Liying Zhang *Bingfeng Lu Bingfeng Lu
  • Second Affiliated Hospital of Guangxi Medical University, Nanning, China

The final, formatted version of the article will be published soon.

    Background: Perivascular epithelioid cell tumours (PEComas) occurring in the uterus are rare. Surgery is the most recommended primary treatment for the malignant cases. This study aimed to provide clinical guidance concerning the clinicopathological features and valid treatment options for the patients with uterine PEComas of uncertain malignant potential.Cases: This case series summarized the clinical courses of 13 patients diagnosed with uterine PEComas of uncertain malignant potential, including clinical and pathological data as well as their outcomes. We identified 1 case at our hospital and data for the other 12 cases were extracted from the PubMed database. The 13 patients were aged 9 -75 years, with tumour sizes ranging from 1 to 21 cm, and follow-up time ranging from 2 to 71 months. The most common signs and symptoms included abnormal uterine bleeding (AUB) and abdominal pain.Most of the patients (11/13) were managed surgically without any chemotherapy or radiation therapy. Except for the patients who were lost to follow-up, 11 patients were free of any recurrence or metastasis at their last follow-up. Patients with Group A tumours (abundant HMB45 expression) had a longer disease-free survival than did those with Group B tumours.Conclusions: Surgery alone may be appropriate for uterine PEComas of uncertain malignant potential. Surgical treatment plans should take the patient's age, fertility requirements and their own will into consideration. Mass resection is a candidate treatment for fertility preservation in reproductive-age patients.

    Keywords: Uterine PEComas, perivascular epithelioid cell, Uncertain malignant potential, Fertility Preservation, case report

    Received: 01 Nov 2024; Accepted: 30 Dec 2024.

    Copyright: © 2024 Shi, Yin, Liang, Liu, Huang, Zhang and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Liying Zhang, Second Affiliated Hospital of Guangxi Medical University, Nanning, China

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