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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1516638
This article is part of the Research Topic Plant-derived Therapeutics and Traditional Medicine: Innovations, Challenges, and Opportunities in Breast Cancer Treatment View all 5 articles

Cellulose Nanofiber Reinforced Curcumin-Infused Calcium Phosphate Silicate Cement for various bone-tissue engineering application

Provisionally accepted
Xiu Guo Lu Xiu Guo Lu 1,2Sha Li Meng Sha Li Meng 1,3*qiu jing Zhou qiu jing Zhou 1,3*Tao Wu Tao Wu 1,3*xing tian Gong xing tian Gong 3*qiong Wu qiong Wu 4*
  • 1 College of Information Science and Engineering, Northeastern University, Shenyang, Liaoning Province, China
  • 2 Department of Nuclear Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning,110016, China, Shen Yang, China
  • 3 Department of Biomedical Engineering, Shenyang University of Technology, Shenyang, China, 110870, Shenyang, China
  • 4 Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China

The final, formatted version of the article will be published soon.

    This study introduces a pioneering approach in bone tissue engineering for addressing defects caused by bone cancer, utilizing a novel injectable curcumin (Cur)-infused calcium phosphate silicate cement (CPSC). The research focuses on evaluating the dual functionality of CPSC-Cur: promoting bone regeneration and exerting cytotoxic effects on osteosarcoma cells. The material's physicochemical properties, biocompatibility with osteoblasts, and cytotoxicity towards osteosarcoma cells were rigorously analyzed. The findings demonstrate that CPSC-Cur significantly prolongs the setting time, which can be optimized by adding silanized cellulose nanofiber (CNF-SH) to achieve a balance between workability and mechanical strength. Biological assessments reveal a pronounced cytotoxic effect on osteosarcoma cells while maintaining minimal toxicity towards pre-osteoblasts, highlighting CPSC-Cur's potential as a promising material for repairing bone defects following cancer removal. This study lays the groundwork for future investigations into CPSC-Cur's in vivo efficacy and its role in the clinical treatment of bone cancer-related defects.

    Keywords: Curcumin, calcium phosphate silicate cement, Bone cancer, Bone repair, Dual functions

    Received: 24 Oct 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Lu, Meng, Zhou, Wu, Gong and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Sha Li Meng, College of Information Science and Engineering, Northeastern University, Shenyang, 110004, Liaoning Province, China
    qiu jing Zhou, College of Information Science and Engineering, Northeastern University, Shenyang, 110004, Liaoning Province, China
    Tao Wu, College of Information Science and Engineering, Northeastern University, Shenyang, 110004, Liaoning Province, China
    xing tian Gong, Department of Biomedical Engineering, Shenyang University of Technology, Shenyang, China, 110870, Shenyang, China
    qiong Wu, Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.