Skip to main content

CASE REPORT article

Front. Oncol.
Sec. Gynecological Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1514471

Case Report: high-grade serous tubo-ovarian carcinoma with FGFR2::IQCG fusion and insights into targetability

Provisionally accepted
Reiri Sono Reiri Sono 1,2Gottfried E. Konecny Gottfried E. Konecny 2*Liying Zhang Liying Zhang 2*
  • 1 University of Texas Health Science Center at Houston, Houston, United States
  • 2 University of California, Los Angeles, Los Angeles, California, United States

The final, formatted version of the article will be published soon.

    FGFR2 fusion is among the classes of emerging therapeutic targets of precision oncology and are observed in many solid tumor types. Our understanding of oncogenic mechanisms and therapy effects of molecular targets tends to reflect those occurring in overrepresented tumor types, posing a challenge in therapy planning of the same targets occurring in unusual tumor types. We present a case of a primary high-grade serous tubo-ovarian carcinoma with a novel FGFR2::IQCG fusion, an exceedingly rare combination of tumor type and fusion class, with an unusually short-lived response to futibatinib. We review the potential pathogenic mechanism of this fusion and address challenges in predicting targeted therapy efficacy using various assay types and trial designs in heterogeneous tumor types sharing a structural variant.

    Keywords: case report, high-grade serous tubo-ovarian cancer1, FGFR2, FGFR2::IQGC, novel fusion

    Received: 21 Oct 2024; Accepted: 22 Nov 2024.

    Copyright: © 2024 Sono, Konecny and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Gottfried E. Konecny, University of California, Los Angeles, Los Angeles, 90095, California, United States
    Liying Zhang, University of California, Los Angeles, Los Angeles, 90095, California, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.