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SYSTEMATIC REVIEW article

Front. Oncol.
Sec. Cancer Genetics
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1512971

Prognostic and Clinicopathological Significance of Mucin Family Members Expression in Gastric Cancer: A Meta-Analysis

Provisionally accepted
Shunda Wang Shunda Wang *Yongrun Mu Yongrun Mu Jianwei Zhang Jianwei Zhang Chengfeng Wang Chengfeng Wang
  • Center for National Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

The final, formatted version of the article will be published soon.

    Mucin family members have been reported to be widely expressed in gastric carcinoma with diverse functions. Several important mucins exert the function of tumorigenesis or progression in gastric cancer. Here we conduct this meta-analysis to evaluate the association between mucin expression and clinicopathological features in gastric cancer.. Literature searches were performed in PubMed, Embase, the Cochrane Library and ISI Web of science, and finally 28 studies met our criteria. Odds ratios (ORs) or hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to evaluate the effect quantity. We analyzed the expression of MUC1, MUC2, MUC5AC, MUC6 and their clinicopathological characteristics separately at the same time.Twenty-eight studies contain 4603 patients were included in our meta-analysis. MUC1 was associated with gender, Lauren classification, depth of tumor invasion, TNM, vascular invasion, lymph metastasis, and lymphatic invasion, WHO grade, as well as the 5-year survival rate. MUC2 was significantly correlated with lymphatic invasion and WHO grade. MUC5AC was highly positive in gender, depth of tumor invasion, WHO grade, TNM, lymph metastasis, and lymphatic invasion.Besides, cases with decreased MUC5AC expression were correlated with less 5-year survival. MUC6 was only related with lymphatic invasion.Our meta-analysis showed that MUC1 and MUC5AC had prognostic value in GC detected by immunohistochemistry. MUC1 and MUC5AC were also associated with some other significant clinicopathological parameters. Besides, MUC2 and MUC6 also exert their influence in lymphatic invasion. However, further enlarged study awaited to verify our conclusion to deeply explore the role of mucin family members in gastric cancer.

    Keywords: MUC1, MUC2, MUC5AC, MUC6, prognosis, Clinicopathological characteristics

    Received: 17 Oct 2024; Accepted: 13 Dec 2024.

    Copyright: © 2024 Wang, Mu, Zhang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Shunda Wang, Center for National Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.