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SYSTEMATIC REVIEW article

Front. Oncol.
Sec. Cancer Epidemiology and Prevention
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1510578
This article is part of the Research Topic Living With and Beyond Cancer Across the Lifespan View all 7 articles

Optimal Exercise Dose-Response Improve Health-Related Quality of Life in Cancer Survivors: A Systematic Review and Bayesian Network Meta-Analysis of RCTs

Provisionally accepted
Zhiyu  Xiong Zhiyu Xiong 1Yuan  Yuan Yuan Yuan 2Yong  Yang Yong Yang 3Bopeng  Qiu Bopeng Qiu 4Ying  Bai Ying Bai 2Tao  Wang Tao Wang 5Junyu  Wang Junyu Wang 6Lin  Zhang Lin Zhang 7Yawen  Li Yawen Li 1*
  • 1 East China Jiaotong University, Nanchang, Jiangxi, China
  • 2 Kunsan National University, Gunsan, North Jeolla, Republic of Korea
  • 3 Chaohu University, Chaohu, Anhui Province, China
  • 4 Beijing Sport University, Beijing, China
  • 5 Southwest University of Science and Technology, Mianyang, Sichuan Province, China
  • 6 Shanghai University of Sport, Shanghai, Shanghai Municipality, China
  • 7 West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Objective: Cancer survivors often face significant health-related quality of life (HRQoL) challenges. Although exercise has been proven to improve HRQoL in cancer survivors, the optimal dose and intensity of exercise for this population has not been fully determined. Adherence to exercise may vary based on exercise intensity, affecting results. This study explored the dose-response relationship of different exercise types and intensities to better understand their impact on HRQoL in cancer survivors.We searched five databases-PubMed, Embase, the Cochrane Library, Web of Science, and Scopus-from their inception until December 1, 2023. Data analysis was performed using R software with the MBNMA and RJAGS packages. Due to combine from different scales, effect sizes were reported as standardized mean differences (SMD) with 95% credible intervals (95% CrI). The risk of bias was assessed independently by two reviewers using the RoB2 tool.Results: A total of 48 studies involving 3088 cancer survivors. Across all exercise types, the most beneficial exercise dose was identified at 850 METs-min/week (SMD: 0.753, 95%Crl: 0.463 to 1.096), with diminishing returns observed beyond 1100 METs-min/week. Among the various types of exercises, mixed training (MT) emerged as the optimal choice, demonstrating its efficacy at 970 METs-min/week (SMD: 0.883, 95% Crl: 0.455 to 1.345). Aerobic exercise (AE) at a dose of 430 METs-min/week (SMD: 0.681, 95% Crl: 0.206 to 1.099) and resistance training (RT) at 450 METsmin/week (SMD: 0.695, 95% Crl: 0.227 to 1.203) also showed significant benefits. Additionally, mind-body exercises, such as Tai Chi, Qigong, or Yoga, exhibited optimal effects at a dose of 390 METs-min/week (SMD: 0.672, 95% Crl: 0.259 to 1.087).Our study sheds light on the intricate relationship between exercise interventions and health-related quality of life in cancer survivors, as elucidated through a systematic review and Bayesian network meta-analysis. The identified optimal exercise dose of 850 METs-min/week signifies a significant improvement in health-related quality of life, underscoring the importance of regular exercise in cancer survivorship. MT emerged as the most effective modality, closely followed by RT, AE, and MBE.

    Keywords: cancer survivor, Exercise, health-related quality of life, dose-response, Bayesian network meta-analysis

    Received: 13 Oct 2024; Accepted: 08 Nov 2024.

    Copyright: © 2024 Xiong, Yuan, Yang, Qiu, Bai, Wang, Wang, Zhang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yawen Li, East China Jiaotong University, Nanchang, 330013, Jiangxi, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.