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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Cardio-Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1509100

Primary cardiac lymphoma: A clinicopathological study of 36 cases

Provisionally accepted
Shuhui Zhuang Shuhui Zhuang 1Liudi Chang Liudi Chang 1,2Xiaoxi Feng Xiaoxi Feng 1,2*Weiwen Hu Weiwen Hu 1,2Zhaobo Yang Zhaobo Yang 1*Yuanyuan Zhang Yuanyuan Zhang 1*
  • 1 Linyi People's Hospital, Linyi, China
  • 2 Shandong Second Medical University, Weifang, Shandong Province, China

The final, formatted version of the article will be published soon.

    Background: Primary cardiac lymphoma (PCL) is an exceedingly uncommon type of lymphoma that primarily affects the heart and/or pericardium, or manifests through cardiac symptoms due to myocardial infiltration. The infrequency of PCL, coupled with its non-specific clinical presentations, often complicates early diagnosis. This study aims to fill the existing gap in clinical knowledge regarding PCL in China by detailing a case of PCL and examining its clinical features, auxiliary examinations, treatment approaches, and prognostic outcomes, thereby facilitating early detection and enhancing patient care.A thorough search of the PubMed and Chinese National Knowledge Infrastructure (CNKI) database was performed using keywords "heart" and "lymphoma" or "primary cardiac lymphoma". This search encompassed publications from January 1, 2014, to November 1, 2024.The review included 121 cases. These cases usually present with atypical symptoms, mainly circulatory and respiratory, including chest tightness, dyspnea, and edema, along with occasional neurological and gastrointestinal symptoms. Echocardiography served as the primary diagnostic method in 92.6% of cases, while a definitive diagnosis was achieved through pathological examination in all cases (100%). Treatment strategies predominantly included surgical intervention (44.6%) and chemotherapy (76.0%). Although surgery did not have a significant effect on survival rates, chemotherapy proved to be critical in improving patient survival.Conclusions: PCL, which arises in the cardiac or pericardial areas, is generally associated with a poor prognosis. It is essential for clinicians to develop a greater awareness and understanding of the characteristics of PCL to enhance early diagnosis. The timely initiation of chemotherapy is vital for improving survival rates and the overall quality of life for patients with PCL.

    Keywords: primary cardiac lymphoma, Diffuse large B-cell lymphoma, diagnosis, Treatment, prognosis

    Received: 10 Oct 2024; Accepted: 10 Dec 2024.

    Copyright: © 2024 Zhuang, Chang, Feng, Hu, Yang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiaoxi Feng, Linyi People's Hospital, Linyi, China
    Zhaobo Yang, Linyi People's Hospital, Linyi, China
    Yuanyuan Zhang, Linyi People's Hospital, Linyi, China

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