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CASE REPORT article

Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1506949

Long-term Survival Was Achieved through Multidisciplinary Treatment of a Patient with Gallbladder Carcinosarcoma Accompanied by KRAS mutation：A Case Report and Literature Review

Provisionally accepted
Yedan Liao Yedan Liao 1Junbo Lai Junbo Lai 2Jilan Yang Jilan Yang 1Tingfeng Long Tingfeng Long 1Xi Wu Xi Wu 1Dan Luo Dan Luo 1Jin Tan Jin Tan 1Ke Zhang Ke Zhang 2Jiadai Tang Jiadai Tang 2Lin Xie Lin Xie 1*
  • 1 Yunnan Cancer Hospital, Kunming, China
  • 2 Kunming Medical University, Kunming, China

The final, formatted version of the article will be published soon.

    Carcinosarcoma of the gallbladder (CSGB) is an extremely rare subtype of primary gallbladder malignancy，which with a high rate of preoperative misdiagnosis due to its nonspecific clinical symptoms and imaging findings, as well as a high rate of recurrence within a short period of time after surgery, resulting in a very poor prognosis.Through a search of the medical literature, we found that there are few reports of CSGB receiving comprehensive treatments and achieving relatively good outcomes. Here, we report a rare case of CSGB with KRAS G12V mutation that achieved survival time of 32 months after receiving a combination of treatments including surgery, chemotherap y, radiotherapy, and immunotherapy, and we conducted a literature review for the disea se with the aim of raising awareness of the disease.

    Keywords: case report, Carcinosarcoma of the gallbladder, KRAS mutation, diagnostic, Treatment, prognosis

    Received: 06 Oct 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Liao, Lai, Yang, Long, Wu, Luo, Tan, Zhang, Tang and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lin Xie, Yunnan Cancer Hospital, Kunming, China

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