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REVIEW article

Front. Oncol.
Sec. Cancer Imaging and Image-directed Interventions
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1503404

The optimization and application of photodynamic diagnosis and autofluorescence imaging in tumor diagnosis and guided surgery: current status and future prospects

Provisionally accepted
Wei Wan Wei Wan 1Huiquan Liu Huiquan Liu 1*Junrong Zou Junrong Zou 2Tianpeng Xie Tianpeng Xie 2*Guoxi Zhang Guoxi Zhang 2*Weihai Ying Weihai Ying 3Xiaofeng Zou Xiaofeng Zou 2*
  • 1 The First Clinical College, Gannan Medical University, Ganzhou, China
  • 2 Institute of Urology, Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
  • 3 Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

The final, formatted version of the article will be published soon.

    Photodynamic diagnosis (PDD) and autofluorescence imaging (AFI) are emerging cancer diagnostic technologies that offer significant advantages over traditional white-light endoscopy in detecting precancerous lesions and early-stage cancers; moreover, they hold promising potential in fluores-cence-guided surgery (FGS) for tumors. However, their shortcomings have somewhat hindered the clinical application of PDD and AFI. Therefore, it is imperative to enhance the efficacy of PDD and AFI, thereby maximizing their potential for practical clinical use. This article reviews the principles, characteristics, current research status, and advancements of PDD and AFI, focusing on analyzing and discussing the optimization strategies of PDD and AFI in tumor diagnosis and FGS scenarios. Considering the practical and technical feasibility, optimizing PDD and AFI may result in an effective realtime diagnostic tool to guide clinicians in tumor diagnosis and surgical guidance to achieve the best results.

    Keywords: Photodynamic diagnosis, Autofluorescence imaging, photosensitizer, tumor, fluorescence-guided surgery, diagnosis, Optimization strategy

    Received: 28 Sep 2024; Accepted: 19 Dec 2024.

    Copyright: © 2024 Wan, Liu, Zou, Xie, Zhang, Ying and Zou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Huiquan Liu, The First Clinical College, Gannan Medical University, Ganzhou, China
    Tianpeng Xie, Institute of Urology, Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
    Guoxi Zhang, Institute of Urology, Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
    Xiaofeng Zou, Institute of Urology, Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.