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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Gynecological Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1499387

The value of multi-parameter radiomics combined with imaging features in predicting the therapeutic efficacy of HIFU treatment for uterine fibroids

Provisionally accepted
Li Shen Li Shen 1Xiao Huang Xiao Huang 1,2Yu y. Liu Yu y. Liu 2Qing x. LI Qing x. LI 2*Shan w. Bai Shan w. Bai 3*Fang Wang Fang Wang 4*Quan Yang Quan Yang 2*
  • 1 Yongchuan Hospital of Chongqing Medical University, Chongqing, China
  • 2 Department of Radiology, The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing, China, Chongqing, China
  • 3 Department of Medical Imaging, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
  • 4 Department of Research and Development, Shanghai United imaging Intelligent Co., Ltd, Shanghai, China, Shanghai, China

The final, formatted version of the article will be published soon.

    Objectives:To evaluate the effectiveness of high-intensity focused ultrasound (HIFU) therapy for treating uterine fibroids by utilizing multi-sequence magnetic resonance imaging radiomic models.:One hundred and fifty patients in our hospital were randomly divided into a training cohort (n=120) and an internal test cohort (n=30), and forty-five patients from another hospital serving as an external test cohort. Radiomics features of uterine fibroids were extracted and selected based on preoperative T2-weighted imaging fat 2586 删除[li shen]: 3 删除[li shen]: suppression(T2WI-FS )and contrast-enhanced T1WI(CE-T1WI)images, and logistic regression was used to develop the T2WI-FS, CE-T1WI, and combined T2WI-FS + CE-T1WI models, along with the radiomics-clinical model integrating radiomics features with imaging characteristics.The performance and clinical applicability of each model were assessed through receiver operating characteristic (ROC) curve , decision curve analysis (DCA), as well as Network Readiness Index (NRI) and Integrated Discrimination Index (IDI). Results:The AUC values of the radiomics-clinical model and the T2WI-FS + CE-T1WI model were the highest. In the training cohort, the radiomics-clinical model showed higher AUC values than the T2WI-FS + CE-T1WI model, while in the internal and external testing cohorts, the AUC values of the T2WI-FS + CE-T1WI model were higher than that of the radiomics-clinical model. DCA further demonstrated that these two models achieved the greatest net benefit. NRI and IDI analyses suggested that the T2WI-FS + CE-T1WI model had higher clinical utility. Conclusions:Both the T2WI-FS + CE-T1WI model and the radiomics-clinical model demonstrate higher predictive value and larger net benefit compared to other models.

    Keywords: High-intensity focused ultrasound, Uterine fibroids, Magnetic Resonance Imaging, Radiomics, therapeutic efficacy

    Received: 20 Sep 2024; Accepted: 04 Nov 2024.

    Copyright: © 2024 Shen, Huang, Liu, LI, Bai, Wang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Qing x. LI, Department of Radiology, The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing, China, Chongqing, China
    Shan w. Bai, Department of Medical Imaging, Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China
    Fang Wang, Department of Research and Development, Shanghai United imaging Intelligent Co., Ltd, Shanghai, China, Shanghai, China
    Quan Yang, Department of Radiology, The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing, China, Chongqing, China

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