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SYSTEMATIC REVIEW article

Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1498854
This article is part of the Research Topic Clinical prediction models in cancer through bioinformatics View all articles

Prognostic value of the pretreatment Naples prognostic score in patients with colorectal cancer: a systematic review and meta-analysis

Provisionally accepted
Hui Liu Hui Liu 1Dailiang Zhu Dailiang Zhu 1Dequan Jiang Dequan Jiang 1Hua-Yang Pang Hua-Yang Pang 2*Xiaolian Yang Xiaolian Yang 1
  • 1 Chongqing University Jiangjin Hospital, Jiangjin, Chongqing Municipality, China
  • 2 Cancer Hospital, Chongqing University, Chongqing, China

The final, formatted version of the article will be published soon.

    Background: The prognostic significance of the Naples prognostic score (NPS) in colorectal cancer remains uncertain. This study aims to investigate the correlation between the pretreatment NPS and long-term oncological outcomes in patients with colorectal cancer. Methods: A comprehensive literature search of electronic databases, including PubMed, Embase, and Web of Science, was conducted up to July 1st, 2024. The primary outcomes assessed were survival outcomes. Subgroup analysis and sensitivity analysis were performed during the pooled analysis. Results: Eight studies including 2571 patients were included. The pooled results indicated that patients in the high NPS group exhibited significantly worse overall survival (HR= 2.08 95%CI: 1.74-2.48; P<0.01; I2=0%) and disease-free survival (HR=2.03; 95%CI: 1.49-2.77; P<0.01; I2=30%). Notably, the prognostic significance of NPS on both overall survival and disease-free survival was consistent across different geographical regions, tumor stages, and primary treatments examined in this study. Furthermore, sensitivity analyses confirmed the robustness of these combined results. Conclusion: The pretreatment NPS could serve as a valuable biomarker for predicting long-term oncological outcomes in patients diagnosed with colorectal cancer.

    Keywords: colorectal cancer, Naples prognostic score, overall survival, Disease-Free Survival, Meta-analysis

    Received: 19 Sep 2024; Accepted: 16 Dec 2024.

    Copyright: © 2024 Liu, Zhu, Jiang, Pang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hua-Yang Pang, Cancer Hospital, Chongqing University, Chongqing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.