This article is a correction to:
Germline Mutations in Patients With Early-Onset Prostate Cancer
Tang Tang1†
Xintao Tan1†
Ze Wang1
Shuo Wang1
Yapeng Wang1
Jing Xu1
Xiajie Wei2
Dianzheng Zhang3
Qiuli Liu1*
Jun Jiang1*- 1Department of Urology, Daping Hospital, Army Medical University, Chongqing, China
- 2Genetron Health (Beijing) Co., Beijing, China
- 3Department of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, United States
A Corrigendum on
Germline mutations in patients with early-onset prostate cancer
By Tang T, Tan X, Wang Z, Wang S, Wang Y, Xu J, Wei X, Zhang D, Liu Q and Jiang J (2022). Front. Oncol. 12:826778. doi: 10.3389/fonc.2022.826778
In the published article, there was an inconsistency between Figures 1 and 2. The mutation types for BRCA1 and BRCA2 are not accurately represented in Figure 1. The information provided in Figures 2 is correct - BRCA1 has two missense variants, and BRCA2 has 3 stop_gained variants, 1 frameshift, and 1 missense variant. The errors in Figure 1 occurred during the figure preparation process, where the mutation types for BRCA2 in patient W082337N and BRCA1 in patient W084213N were incorrectly color-coded. The corrected Figure 1 and its caption appear below.
Figure 1
Figure 1. A waterfall plot shows the mutation ratio, mutation type of the mutated genes, and the clinical features of the 24 patients. The top panel shows the number of the mutations in each PCa sample; the left panel shows the frequently mutated genes; the right panel shows the detection ratio of each mutated gene; the bottom panel shows the sample number and the clinical features of the corresponding patient.
In the published article, a correction has been made to Results, Cases and Pedigrees, Paragraph 1. The mutation listed for Patient A should be BRCA2 c.1799_1804del, p.Tyr600_Gly602delinsTer, as shown in Table 2 and Figure 3. This sentence previously stated:
“Results from Sanger sequencing indicate that his healthy brother shares the same germline mutation of BRCA2 (c.4211C>G, p.S1404Ter), and his father died of bladder cancer at the age of 60.”
The corrected sentence appears below:
“Results from Sanger sequencing indicate that his healthy brother shares the same germline mutation of BRCA2 (c.1799_1804del, p.Tyr600_Gly602delinsTer), and his father died of bladder cancer at the age of 60.”
The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: prostate cancer, early-onset, next-generation sequencing, germline mutations, homologous recombination associated genes
Citation: Tang T, Tan X, Wang Z, Wang S, Wang Y, Xu J, Wei X, Zhang D, Liu Q and Jiang J (2024) Corrigendum: Germline mutations in patients with early-onset prostate cancer. Front. Oncol. 14:1498329. doi: 10.3389/fonc.2024.1498329
Received: 18 September 2024; Accepted: 04 December 2024;
Published: 18 December 2024.
Edited and Reviewed by:
Ronald M. Bukowski, Cleveland Clinic, United StatesCopyright © 2024 Tang, Tan, Wang, Wang, Wang, Xu, Wei, Zhang, Liu and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Qiuli Liu, bGl1cWl1bGk5MDA4MjdAMTYzLmNvbQ==; Jun Jiang, amlhbmdqdW5fNjRAMTYzLmNvbQ==
†These authors have contributed equally to this work and share first authorship